FITC标记的RAS相关GTP结合蛋白C抗体上海沪震实业有限公司

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产品名称: FITC标记的RAS相关GTP结合蛋白C抗体
英文名称: Anti-RRAGC/FITC
抗体货号: HZ-10097R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: Flow-Cyt=1ug/Test ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/13 10:53:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-RRAGC/FITC Conjugated antibody

FITC标记的RAS相关GTP结合蛋白C抗体

 

英文名称 Anti-RRAGC/FITC
中文名称 FITC标记的RAS相关GTP结合蛋白C抗体
别    名 RAGC; TIB929; YGR163W; GTPase interacting protein 2; GTPase-interacting protein 2; GTR2; Rag C; Rag C protein; Ras related GTP binding C; Ras-related GTP-binding protein C; RP23 29H22.4; RRAGC; RRAGC_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  染色质和核信号  信号转导  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 Flow-Cyt=1ug/Test ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RRAGC
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].

Function:
Has guanine nucleotide-binding activity but weak intrinsic GTPase activity. Probably required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.

Subunit:
Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB.

Subcellular Location:
Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA.

Similarity:
Belongs to the GTR/RAG GTP-binding protein family.

Database links:

Entrez Gene: 64121 Human

Entrez Gene: 54170 Mouse

Entrez Gene: 100528436 Pig

Entrez Gene: 298514 Rat

Omim: 608267 Human

SwissProt: Q9HB90 Human

SwissProt: Q99K70 Mouse

Unigene: 532461 Human

Unigene: 220922 Mouse

Unigene: 473825 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
Blank control: Mouse spleen. 
Primary Antibody (green line): Rabbit Anti-RRAGC antibody (bs-10097R) 
Dilution: 1μg /10^6 cells; 
Isotype Control Antibody (orange line): Rabbit IgG .
Dilution: 1μg /test. 
Protocol
The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at-20℃. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. Acquisition of 20,000 events was performed.

Blank control (Black line): Mouse spleen. 
Primary Antibody (green line): Rabbit Anti-RRAGC antibody (bs-10097R) 
Dilution: 1μg /10^6 cells; 
Isotype Control Antibody (orange line): Rabbit IgG .
Dilution: 1μg /test. 
Protocol
The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at-20℃. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. Acquisition of 20,000 events was performed
   

该基因编码GTR/RAG-GTP结合蛋白家族的一个成员。编码蛋白是单体鸟嘌呤核苷酸结合蛋白,它与RRAGA和RRAGB形成异二聚体,主要定位于细胞质。编码的蛋白促进mTOR复合物的细胞内定位。选择性剪接导致多个转录变体。[ RefSeq,DEC 2012 ]提供。

 

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