FITC标记的S100钙结合蛋白A6抗体
产品名称： FITC标记的S100钙结合蛋白A6抗体
英文名称： Anti-S100A6/FITC
产品编号： HZ-10098R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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- 邮编 : 200612
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Rabbit Anti-S100A6/FITC Conjugated antibody
FITC标记的S100钙结合蛋白A6抗体
| 英文名称 | Anti-S100A6/FITC |
| 中文名称 | FITC标记的S100钙结合蛋白A6抗体 |
| 别 名 | S100 alpha 6 PRA; Calcyclin; PRAGrowth factor inducible protein 2A9; Prolactin receptor associated protein; Prolactin receptor-associated protein; Protein S100 A6; Protein S100-A6; S100 A6; S100 calcium binding protein A6 (calcyclin); S100 calcium binding protein A6; S100 calcium-binding protein A6; S100A6; S100A6_HUMAN; S100-A6; 2A9; 5B10; CABP; CACY; Calcyclin; Growth factor inducible protein 2A9; Growth factor-inducible protein 2A9; MLN 4; MLN4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 信号转导 生长因子和激素 细胞因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 10kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human S100A6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Calcyclin, also known as Protein S100-A6, growth factor-inducible protein 2A9, S-100 calcium-binding protein A6 (S-100A6) or MLN 4, is a homodimeric member of the S-100 calcium-binding protein family whose expression is upregulated in proliferating and differentiating cells. Calcyclin is inducible by growth factors and overexpressed in acute myeloid leukemias. It is expressed in a cell-specific manner in subpopulations of neurons and astrocytes and in epithelial cells and fibroblasts. Calcyclin is a specific target of S-100B protein in vivo. The binding of Calcyclin to S-100B is stabilized by S-100B-bound calcium and zinc. Calcyclin associates with both Annexin XI and CacyBP (calcyclin-binding protein). It functions to activate several processes along the calcium signal transduction pathway including the regulation of cell growth, proliferation, secretion and exocytosis. Function: May function as calcium sensor and contribute to cellular calcium signaling (Potential). May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. Subunit: Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with CACYBP in a calcium-dependent manne. Subcellular Location: Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Post-translational modifications: The N-terminus is blocked. Similarity: Belongs to the S-100 family. Database links: Entrez Gene: 6277 Human Entrez Gene: 20200 Mouse Entrez Gene: 85247 Rat Omim: 114110 Human SwissProt: P06703 Human SwissProt: P14069 Mouse SwissProt: P05964 Rat Unigene: 275243 Human Unigene: 100144 Mouse Unigene: 3233 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Calcyclin，也称为蛋白S100-A6，生长因子诱导蛋白2A9，S-100钙结合蛋白A6（S-100A6）或MLN 4，是S-100钙结合蛋白家族的同源二聚体成员，其表达在增殖和分化细胞中上调。Calcyclin是由生长因子诱导的，在急性髓性白血病中过表达。它以神经元特异性的方式在神经元和星形胶质细胞和上皮细胞和成纤维细胞亚群中表达。钙周期蛋白是体内S-100B蛋白的特异性靶点。Calcyclin与S-100B的结合是由S-100B结合的钙和锌稳定的。钙结合蛋白与膜联蛋白XI和CacyBP（钙周期蛋白结合蛋白）结合。它的作用是激活钙信号转导途径中的几个过程，包括调节细胞生长、增殖、分泌和胞吐作用。