FITC标记的20号染色体开放阅读框14抗体上海沪震实业有限公司

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产品名称: FITC标记的20号染色体开放阅读框14抗体
英文名称: Anti-C20orf14/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/13 11:21:00
详细资料:  实验方法技术资料
浏览人数:13
诚信指数:962点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
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电话:
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联系人:
陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-C20orf14/FITC Conjugated antibody

FITC标记的20号染色体开放阅读框14抗体

 

英文名称 Anti-C20orf14/FITC
中文名称 FITC标记的20号染色体开放阅读框14抗体
别    名 Androgen receptor N terminal domain transactivating protein 1; Chromosome 20 open reading frame 14; fc12b02; hypothetical protein LOC323855; p102 U5 small nuclear ribonucleoprotein particle binding protein; Pre mRNA processing factor 6; PRP6 homolog; PRPF 6; PRPF6; Putative mitochondrial outer membrane protein import receptor; U5 102 kDa protein; U5 snRNP associated 102 kDa protein; wu:fa05f07; wu:fc12b02; zgc:65913; PRP6_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  染色质和核信号  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 107kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human C20orf14
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.

Function:
Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances ***-induced transactivation activity of AR, as well as ***-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. 

Subunit:
Associates with the U5 snRNP particle. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39, LSm proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Identified in the spliceosome C complex. Interacts with AR and NR3C1, but not ESR1, independently of the presence of hormones.

Subcellular Location:
Nucleus, nucleoplasm. Nucleus speckle. Note=Localized in splicing speckles.

Tissue Specificity:
Widely expressed.

DISEASE:
Defects in PRPF6 may be the cause of retinitis pigmentosa type 60 (RP60) [MIM:613983]. A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Note=Cells from RP60 patients show intron retention for pre-mRNA bearing specific splicing signals. 

Similarity:
Contains 9 HAT repeats. 

Database links:
UniProtKB/Swiss-Prot: O94906.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

该基因编码的蛋白似乎参与前mRNA剪接,可能作为连接体形成的U5和U4/U6snRNP之间的桥接因子。编码的蛋白质也可以结合雄受体,提供转录激活和剪接之间的联系。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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