FITC标记的4-磷酸磷脂酰肌醇5激酶1样蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的4-磷酸磷脂酰肌醇5激酶1样蛋白抗体
英文名称: Anti-PIP5KL1/FITC
抗体货号: HZ-0451R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/13 11:40:00
详细资料:  实验方法技术资料
浏览人数:4
诚信指数:950点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-PIP5KL1/FITC Conjugated antibody

FITC标记的4-***酸***脂酰肌醇5激酶1样蛋白抗体

 

英文名称 Anti-PIP5KL1/FITC
中文名称 FITC标记的4-***酸***脂酰肌醇5激酶1样蛋白抗体
别    名 bA203J24.5; EC 2.7.1.68; MGC46424; phosphatidylinositol 4 phosphate 5 kinase like 1; phosphatidylinositol phosphate kinase homolog; Phosphatidylinositol-4-phosphate 5-kinase-like protein 1; PI(4)P 5 kinase like protein 1; PI(4)P 5-kinase-like protein 1; PI5L1_HUMAN; PIP5KL1; PIPKH; PtdIns(4)P 5 kinase like protein 1; PtdIns(4)P-5-kinase-like protein 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PIP5KL1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
PIPKH, also known as PIP5KL1 (phosphatidylinositol-4-phosphate 5-kinase-like 1), is a 394 amino acid phosphoinositide kinase-like protein that contains one PIPK domain. Although PIPKH lacks intrinsic lipid kinase activity, it associates with type I PIPKs and may play a role in localization of PIPK activity. Encoded by a gene that maps to human chromosome 9q34.11, PIPKH localizes to cytoplasm, specifically to large cytoplasmic vesicular structures, and exists as two alternatively spliced isoforms. Highly expressed in brain and testis, PIPKH is also expressed at very low levels in heart, spleen, lung, liver, skeletal muscle and kidney. PIPKH heterodimerizes with other type I phosphatidylinositol-4-phosphate 5-kinases, and may function as a scaffold to localize and regulate kinases to specific cell compartments. Overexpression of PIPKH may suppress cell proliferation and migration in human gastric cancer cells and may also inhibit cervical cancer formation.

Function:
May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.

Subunit:
Heterodimerizes with other type I phosphatidylinositol 4-phosphate 5-kinase.

Subcellular Location:
Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures.

Similarity:
Contains 1 PIPK domain.

Database links:

Entrez Gene: 138429 Human

Omim: 612865 Human

SwissProt: Q5T9C9 Human

Unigene: 445486 Human

Unigene: 734928 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

PIPKH又称PIP5KL1(***脂酰肌醇-4-***酸5-激酶样1),是一种394个氨基酸的***脂酰肌醇激酶样蛋白,含有一个PIPK结构域。尽管PIPKH缺乏内在的脂激酶活性,但它与I型PIPK相关,可能在PIPK活性的定位中发挥作用。PIPKH基因编码人染色体9q34.11,定位于细胞质,特异于大的细胞质囊泡结构,并以两种可选择的剪接异构体存在。PIPKH在脑和睾丸中高表达,在心脏、脾脏、肺、肝脏、骨骼肌和肾脏中低表达。PIPKH与其他类型的I型***脂酰肌醇-4-***酸5-激酶异二聚体,并且可以充当支架以定位和调节激酶到特定的细胞室。PIPKH过表达可抑制人胃癌细胞的增殖和迁移,也可抑制宫颈癌的形成。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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