FITC标记的Wnt通路抑制因子2抗体上海沪震实业有限公司

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产品名称: FITC标记的Wnt通路抑制因子2抗体
英文名称: Anti-DKK2/FITC
抗体货号: HZ-13005R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/13 11:42:00
详细资料:  实验方法技术资料
浏览人数:10
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-DKK2/FITC Conjugated antibody

FITC标记的Wnt通路抑制因子2抗体

 

英文名称 Anti-DKK2/FITC
中文名称 FITC标记的Wnt通路抑制因子2抗体
别    名 Dickkopf 2; Dickkopf gene 2; Dickkopf homolog 2; Dickkopf related protein 2; Dickkopf-2; Dickkopf-related protein 2; Dickkopf2; DKK 2; Dkk-2; Dkk2; DKK2_HUMAN; hDkk 2; hDkk-2; hDkk2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  神经生物学  干细胞  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DKK2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The Wnt genes are a group of well conserved, cysteine-rich secreted glycoproteins that are required for numerous develop-mental processes including embryogenesis, asymmetric cell division and central nervous system (CNS) patternins. Wnt association with the seven membrane spanning receptor Frizzled, activates Dishevelled, which downregulates glycogen synthase kinase (GSK) through serine phosphorylation, causing the accumulation of b-Catenin and subsequent regulation of developmentally significant Wnt target genes. The Dickkopf family of secreted inhibitors of Wnt signaling ensures proper morphological development by antagonizing different stages of the Wnt cascade. Dkk-2 (Dickkopf-2) is a 259-amino acid secreted protein that is composed of an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a 50-55-amino acid linker region.

Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Subunit:
Interacts with LRP5 and LRP6 (By similarity). 

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in heart, brain, skeletal muscle and lung.

Post-translational modifications:
May be proteolytically processed by a furin-like protease.

Similarity:
Belongs to the dickkopf family.

Database links:

Entrez Gene: 27123 Human

Entrez Gene: 56811 Mouse

Omim: 605415 Human

SwissProt: Q9UBU2 Human

SwissProt: Q9QYZ8 Mouse

SwissProt: Q9DDA4 Xenopus laevis

Unigene: 211869 Human

Unigene: 103593 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

Wnt基因是一组高度保守、富含半胱氨酸的分泌糖蛋白,是胚胎发生、不对称细胞分裂和中枢神经系统(CNS)等多种发育心理过程所必需的。Wnt与7个跨膜受体Frizzled结合,激活Dishevelled,后者通过丝氨酸***酸化下调糖原合成酶激酶(GSK),导致b-Cat.的积累和随后对发育上重要的Wnt靶基因的调节。Dickkopf家族分泌的Wnt信号传导抑制剂通过拮抗Wnt级联的不同阶段来确保适当的形态发育。Dkk-2(Dickkopf-2)是由N端信号肽和2个富含半胱氨酸的保守结构域组成的259个氨基酸分泌蛋白,由50-55个氨基酸连接区组成。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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