FITC标记的Wnt通路抑制因子2抗体
产品名称： FITC标记的Wnt通路抑制因子2抗体
英文名称： Anti-DKK2/FITC
产品编号： HZ-13005R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-DKK2/FITC Conjugated antibody
FITC标记的Wnt通路抑制因子2抗体
| 英文名称 | Anti-DKK2/FITC |
| 中文名称 | FITC标记的Wnt通路抑制因子2抗体 |
| 别 名 | Dickkopf 2; Dickkopf gene 2; Dickkopf homolog 2; Dickkopf related protein 2; Dickkopf-2; Dickkopf-related protein 2; Dickkopf2; DKK 2; Dkk-2; Dkk2; DKK2_HUMAN; hDkk 2; hDkk-2; hDkk2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 神经生物学 干细胞 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DKK2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Wnt genes are a group of well conserved, cysteine-rich secreted glycoproteins that are required for numerous develop-mental processes including embryogenesis, asymmetric cell division and central nervous system (CNS) patternins. Wnt association with the seven membrane spanning receptor Frizzled, activates Dishevelled, which downregulates glycogen synthase kinase (GSK) through serine phosphorylation, causing the accumulation of b-Catenin and subsequent regulation of developmentally significant Wnt target genes. The Dickkopf family of secreted inhibitors of Wnt signaling ensures proper morphological development by antagonizing different stages of the Wnt cascade. Dkk-2 (Dickkopf-2) is a 259-amino acid secreted protein that is composed of an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a 50-55-amino acid linker region. Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Subunit: Interacts with LRP5 and LRP6 (By similarity). Subcellular Location: Secreted. Tissue Specificity: Expressed in heart, brain, skeletal muscle and lung. Post-translational modifications: May be proteolytically processed by a furin-like protease. Similarity: Belongs to the dickkopf family. Database links: Entrez Gene: 27123 Human Entrez Gene: 56811 Mouse Omim: 605415 Human SwissProt: Q9UBU2 Human SwissProt: Q9QYZ8 Mouse SwissProt: Q9DDA4 Xenopus laevis Unigene: 211869 Human Unigene: 103593 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Wnt基因是一组高度保守、富含半胱氨酸的分泌糖蛋白，是胚胎发生、不对称细胞分裂和中枢神经系统（CNS）等多种发育心理过程所必需的。Wnt与7个跨膜受体Frizzled结合，激活Dishevelled，后者通过丝氨酸磷酸化下调糖原合成酶激酶（GSK），导致b-Cat.的积累和随后对发育上重要的Wnt靶基因的调节。Dickkopf家族分泌的Wnt信号传导抑制剂通过拮抗Wnt级联的不同阶段来确保适当的形态发育。Dkk-2(Dickkopf-2)是由N端信号肽和2个富含半胱氨酸的保守结构域组成的259个氨基酸分泌蛋白，由50-55个氨基酸连接区组成。