FITC标记的DHX15蛋白抗体
产品名称： FITC标记的DHX15蛋白抗体
英文名称： Anti-DHX15/FITC
产品编号： HZ-13001R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DHX15/FITC Conjugated antibody
FITC标记的DHX15蛋白抗体
| 英文名称 | Anti-DHX15/FITC |
| 中文名称 | FITC标记的DHX15蛋白抗体 |
| 别 名 | ATP dependent RNA helicase #46; DBP1; DDX15; DEADH box 15; DEAH (Asp Glu Ala His) box polypeptide 15; DEAH box polypeptide 15; DEAH box protein 15; HRH2; PRP43; PrPp43p; RNA; DHX15_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 91kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DHX15 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DEAD-box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure and ribosome/spliceosome assembly. Based on their distribution patterns, some members of this family may be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX15 (DEAH-box protein 15), also known as DHX15, DBP1 or HRH2, is a nuclear ATP-dependent RNA helicase that is involved in pre-mRNA splicing and is a member of the DEAH-box subfamily of DEAD-box proteins. Expressed throughout the body, DDX15 is a pre-mRNA processing factor that plays a role in spliceosome disassembly after the release of mature mRNA. When localized to the nucleoli, DDX15 is thought to interact with the La/SSB autoantigen, an RNA chaperone that functions in various intracellular processes. DDX15 is 795 amino acids in length and is the human ortholog of the S. cerevisiae protein Prp43. helicase 2. Function: The protein encoded by DHX15 is a putative pre mRNA splicing factor ATP dependent RNA helicase. It is thought to be involved in the disassembly of spliceosomes after the release of mature mRNA, and has been implicated in pre mRNA splicing. Subunit: Interacts with SSB/La. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Subcellular Location: Nucleus. Nucleus, nucleolus. Tissue Specificity: Ubiquitous. Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Database links: UniProtKB/Swiss-Prot: O43143.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic |
DEAD-box蛋白是以Asp-Glu-Ala-Asp保守基序为特征的假定RNA螺旋酶，与涉及RNA二级结构修饰和核糖体/剪接体组装的若干细胞过程有关。根据其分布模式，该家族的一些成员可能参与胚胎发生、精子发生和细胞生长和分裂。DDX15(DEAH-box蛋白15)又称DHX15、DBP1或HRH2，是一种核ATP依赖性RNA螺旋酶，参与前mRNA剪接，是DEAD-box蛋白DEAH-box亚家族的成员。DDX15表达于全身，是mRNA前处理因子，在成熟mRNA释放后参与剪接体的拆卸。当定位于核仁时，DDX15被认为与La/SSB自身抗原相互作用，La/SSB自身抗原是一种RNA伴侣，在多种细胞内过程起作用。DDX15的长度为795个氨基酸，是酿酒酵母蛋白Prp43的人类直系同源物。解旋酶2。