FITC标记的甘油二酯酰基转移酶2抗体
产品名称： FITC标记的甘油二酯酰基转移酶2抗体
英文名称： Anti-DGAT2/FITC
产品编号： HZ-12998R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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- 邮编 : 200612
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Rabbit Anti-DGAT2/FITC Conjugated antibody
FITC标记的甘油二酯酰基转移酶2抗体
| 英文名称 | Anti-DGAT2/FITC |
| 中文名称 | FITC标记的甘油二酯酰基转移酶2抗体 |
| 别 名 | DGAT2; DGAT2_HUMAN; Diacylglycerol O acyltransferase like protein 2; Diacylglycerol O-acyltransferase 2; Diacylglycerol O-acyltransferase homolog 2 (mouse); Diacylglycerol O-acyltransferase homolog 2; Diacylglycerol O-acyltransferase-like protein 2 isoform 1; Diglyceride acyltransferase 2; DKFZp686A15125; GS1999full; HMFN1045. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 信号转导 细胞类型标志物 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DGAT2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Glucose and insulin are anabolic signals which upregulate the transcriptions of a series of lipogenic enzymes to convert excess carbohydrate into triglycerides for efficient energy storage. Acyl-coenzyme A:diacylglycerol acyltransferase, also known as DGAT1 and ARGP1, is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT1 catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT1 plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism, such as intestinal fat absorption, lipoprotein assembly, adipose tissue form-ation and lactation. DGAT2, which has no homology to DGAT1, differs from DGAT1 in that its activity has been shown to be inhibited by MgCl in an in vitro assay. DGAT2 is expressed primarily in liver and white adipose tissue, which suggests that it plays an important role in mammalian triglyceride metabolism. Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. Subunit: Forms multimeric complexes consisting of several DGAT2 subunits (By similarity). Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. Similarity: Belongs to the diacylglycerol acyltransferase family. Database links: UniProtKB/Swiss-Prot: Q96PD7.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
葡萄糖和胰岛素是合成信号，它们上调一系列成脂酶的转录，以将过量的碳水化合物转化为甘油三酯，从而有效地储存能量。酰基辅酶A:二酰基甘油酰基转移酶，也称为DGAT1和ARGP1，是一种微粒体酶，有助于脂肪酸合成为甘油三酯。DGAT1以二酰甘油（DAG）和脂肪酰基辅酶A（CoA）为底物，催化三酰甘油合成中的末端步骤。DGAT1在细胞二酰基甘油的代谢中起基础作用，在高等真核细胞中对涉及三酰基甘油代谢的生理过程如肠脂肪吸收、脂蛋白组装、脂肪组织形成和泌乳有重要作用。DGAT2与DGAT1无同源性，与DGAT1不同之处在于，在体外实验中，MgCl抑制了DGAT2的活性。DGAT2主要表达于肝脏和白色脂肪组织，提示其在哺乳动物甘油三酯代谢中起重要作用。