FITC标记的减数分裂同源蛋白DMC1抗体上海沪震实业有限公司

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产品名称: FITC标记的减数分裂同源蛋白DMC1抗体
英文名称: Anti-DMC1/FITC
抗体货号: HZ-13010R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/13 11:53:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-DMC1/FITC Conjugated antibody

FITC标记的减数分裂同源蛋白DMC1抗体

 

英文名称 Anti-DMC1/FITC
中文名称 FITC标记的减数分裂同源蛋白DMC1抗体
别    名 disrupted meiotic cDNA 1 homolog; dJ199H16.1; DMC 1; DMC1 dosage suppressor of mck1 homolog; DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast); DMC1 homologue; DMC1H; HsLim15; LIM15; Meiotic recombination protein DMC1/LIM15 homolog; MGC150472; MGC150473; DMC1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞分化  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DMC1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the double-strand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alternative spliced form of Dmc1, designated Dmc1-D, is deleted for a region between the two motifs involved in nucleotide binding. The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis.

Function:
May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (By similarity). 

Subunit:
Interacts with the MND1-PSMC3IP heterodimer (By similarity). Double stacked ring-shaped homooctamer. Interacts with BRCA2. 

Subcellular Location:
Nucleus (Potential). Chromosome (By similarity). 

Similarity:
Belongs to the RecA family. DMC1 subfamily. 
Contains 1 HhH domain.

Database links:
UniProtKB/Swiss-Prot: Q14565.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

DNA修复蛋白是维持染色体完整性所必需的,并且参与从DNA中消除未成年损伤。DNA修复蛋白RAD51和RAD52是双链断裂修复(DSBR)途径的重要组成部分。Rad51是有丝分裂和减数分裂重组所必需的,它在酵母和哺乳动物细胞中的突变导致染色体丢失。RAD52的过度表达赋予电离辐射抗性,并诱导同源染色体内重组。RAD52被认为参与RAD51介导的重组的早期阶段。参与该途径的其他蛋白包括NiBrin和DMC1。NiBRIN,与MeRe11和RAD50的复合物,在NijeMeGe断裂综合征(NBS)患者中不存在。DMC1特异参与减数分裂重组。在涉及核苷酸结合的两个基序之间的区域,Dmc1的另一种剪接形式Dmc1-D被删除。在雄性生殖细胞和雌性生殖细胞中都检测到Dmc1-D转录体的选择性剪接,表明该编码蛋白可能在哺乳动物减数分裂中的遗传重组中发挥作用。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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