FITC标记的DNA聚合酶η抗体
产品名称： FITC标记的DNA聚合酶η抗体
英文名称： Anti-DNA polymerase eta/FITC
产品编号： HZ-13016R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-DNA polymerase eta/FITC Conjugated antibody
FITC标记的DNA聚合酶η抗体
| 英文名称 | Anti-DNA polymerase eta/FITC |
| 中文名称 | FITC标记的DNA聚合酶η抗体 |
| 别 名 | DNA polymerase eta; FLJ16395; FLJ21978; POLH; POLH_HUMAN; polymerase DNA directed eta; RAD30; RAD30 homolog A; RAD30A; Xeroderma pigmentosum variant type protein; XP V; XPV. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 78kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DNA polymerase eta |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Function: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. Subunit: Interacts with REV1 (By similarity). Interacts with monoubiquitinated PCNA, but not unmodified PCNA. Interacts with POLI. Subcellular Location: Nucleus. Accumulates at replication forks after DNA damage. DISEASE: Defects in POLH are the cause of xeroderma pigmentosum variant type (XPV) [MIM:278750]; also designated as XP-V. Xeroderma pigmentosum (XP) is an autosomal recessive disease due to deficient nucleotide excision repair. It is characterized by hypersensitivity of the skin to sunlight, followed by high incidence of skin cancer and frequent neurologic abnormalities. XPV shows normal nucleotide excision repair, but an exaggerated delay in recovery of replicative DNA synthesis. Most XPV patients do not develop clinical symptoms and skin neoplasias until a later age. Clinical manifestations are limited to photo-induced deterioration of the skin and eyes. Similarity: Belongs to the DNA polymerase type-Y family. Contains 1 umuC domain. Database links: UniProtKB/Swiss-Prot: Q9Y253.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DNA聚合酶特异性参与DNA修复。在损伤合成中起着重要作用，正常高保真度DNA聚合酶不能进行和DNA合成停滞。在紫外诱导嘧啶二聚体的修复中起着重要作用。根据上下文，它插入正确的碱基，但会导致频繁的碱基转移和颠倒。可能在免疫球蛋白基因的超突变中起作用。在碱基位点形成具有5’-脱氧核糖磷酸的希夫碱，但不具有裂解酶活性。靶向复制灶的POLI。