FITC标记的转录调节因子E2F7抗体上海沪震实业有限公司

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产品名称: FITC标记的转录调节因子E2F7抗体
英文名称: Anti-E2F7/FITC
抗体货号: HZ-13045R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 8:56:00
详细资料:  实验方法技术资料
浏览人数:8
诚信指数:1084点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-E2F7/FITC Conjugated antibody 

FITC标记的转录调节因子E2F7抗体

 

英文名称 Anti-E2F7/FITC
中文名称 FITC标记的转录调节因子E2F7抗体
别    名 E2F 7; E2F transcription factor 7; E2F-7; E2f7; E2F7_HUMAN; FLJ12981; Transcription factor E2F7.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  信号转导  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 100kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human E2F7
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The human retinoblastoma gene product appears to play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 is a member of a broader family of transcription regulators including E2F-2, E2F-3, E2F-4, E2F-5, E2F-6 and E2F-7 each of which forms heterodimers with a second protein, DP-1, forming an “active” E2F transcriptional regulatory complex.

Function:
Along with E2F8, inhibitor of E2F-dependent transcription that is important for the control of the E2F1-TP53 apoptotic pathway. Directly represses E2F1 transcription (By similarity). Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.

Subunit:
Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA-binding. Interacts with HIF1A. 

Subcellular Location:
Nucleus.

Similarity:
Belongs to the E2F/DP family.

Database links:

Entrez Gene: 144455 Human

Entrez Gene: 52679 Mouse

Entrez Gene: 314818 Rat

Omim: 612046 Human

SwissProt: E1BE02 Cow

SwissProt: Q96AV8 Human

SwissProt: Q6S7F2 Mouse

SwissProt: D4A4D7 Rat

Unigene: 416375 Human

Unigene: 11747 Mouse

Unigene: 211183 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

人视网膜母细胞瘤基因产物在细胞增殖负调控中发挥重要作用。Rb的功能失活可以通过突变或与DNA肿瘤病毒编码蛋白相互作用来介导。迄今为止所描述的所有Rb关联中,Rb和转录因子E2F之间的复合物的鉴定最直接地涉及Rb对细胞增殖的调节。E2F最初通过其在腺病毒E2启动子转录激活中的作用而被鉴定。与E2F结合位点同源的序列已经在许多基因的上游发现,这些基因编码在细胞周期的G1和S期具有假定功能的蛋白质。E2F-1是包括E2F-2、E2F-3、E2F-4、E2F-5、E2F-6和E2F-7在内的转录调节因子家族中的一员,每个转录调节因子都与第二蛋白DP-1形成异源二聚体,形成E2F转录调节复合物。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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