FITC标记的粒细胞-巨噬细胞集落刺激因子受体α抗体上海沪震实业有限公司

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产品名称: FITC标记的粒细胞-巨噬细胞集落刺激因子受体α抗体
英文名称: Anti-GM-CSFR alpha/FITC
抗体货号: HZ-10078R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 8:57:00
详细资料:  实验方法技术资料
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诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-GM-CSFR alpha/FITC Conjugated antibody

FITC标记的粒细胞-巨噬细胞集落刺激因子受体α抗体

 

英文名称 Anti-GM-CSFR alpha/FITC
中文名称 FITC标记的粒细胞-巨噬细胞集落刺激因子受体α抗体
别    名 GM-CSF Receptor alpha; CD116; CD116 antigen; Colony Stimulating Factor 2 Receptor Alpha; Colony stimulating factor 2 receptor alpha chain; CSF 2R; CSF2RA; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM CSF R alpha; GM CSF receptor alpha subunit; GMCSFR; GMR; Granulocyte Macrophage Colony Stimulating Factor Receptor Alpha Chain; GM-CSF-R-alpha; GMCSFR-alpha; GMR-alpha; CDw116; CSF2R_HUMAN; Granulocyte-macrophage colony-stimulating factor receptor subunit alpha.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  干细胞  细胞表面分子  细胞类型标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Dog, Cow, Horse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GM-CSFR alpha
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq].

Function:
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

Subunit:
Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted (Probable). Isoform 4: Secreted (Probable). Isoform 6: Secreted (Probable).

DISEASE:
Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Similarity : Belongs to the type I cytokine receptor family. Type 5 subfamily.

Database links:

Entrez Gene: 1438 Human

Entrez Gene: 12982 Mouse

Omim: 306250 Human

SwissProt: P15509 Human

SwissProt: Q00941 Mouse

Unigene: 520937 Human

Unigene: 287228 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

该基因编码的蛋白质是集落刺激因子2异二聚体受体的α亚单位,集落刺激因子2是一种控制粒细胞和巨噬细胞的产生、分化和功能的细胞因子。编码的蛋白质是受体的细胞因子家族的成员。该基因存在于X染色体和Y染色体的假常染色体区(PAR)中。已发现该基因的多个转录体变异体编码不同的异构体,其中一些异构体是膜结合的,另一些是可溶的。[由RefSeq提供]。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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