FITC标记的粒细胞-巨噬细胞集落刺激因子受体α抗体
产品名称: FITC标记的粒细胞-巨噬细胞集落刺激因子受体α抗体
英文名称: Anti-GM-CSFR alpha/FITC
产品编号: HZ-10078R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GM-CSFR alpha/FITC Conjugated antibody
FITC标记的粒细胞-巨噬细胞集落刺激因子受体α抗体
英文名称 | Anti-GM-CSFR alpha/FITC |
中文名称 | FITC标记的粒细胞-巨噬细胞集落刺激因子受体α抗体 |
别 名 | GM-CSF Receptor alpha; CD116; CD116 antigen; Colony Stimulating Factor 2 Receptor Alpha; Colony stimulating factor 2 receptor alpha chain; CSF 2R; CSF2RA; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM CSF R alpha; GM CSF receptor alpha subunit; GMCSFR; GMR; Granulocyte Macrophage Colony Stimulating Factor Receptor Alpha Chain; GM-CSF-R-alpha; GMCSFR-alpha; GMR-alpha; CDw116; CSF2R_HUMAN; Granulocyte-macrophage colony-stimulating factor receptor subunit alpha. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 干细胞 细胞表面分子 细胞类型标志物 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Dog, Cow, Horse, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 42kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human GM-CSFR alpha |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq]. Function: Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted (Probable). Isoform 4: Secreted (Probable). Isoform 6: Secreted (Probable). DISEASE: Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Similarity : Belongs to the type I cytokine receptor family. Type 5 subfamily. Database links: Entrez Gene: 1438 Human Entrez Gene: 12982 Mouse Omim: 306250 Human SwissProt: P15509 Human SwissProt: Q00941 Mouse Unigene: 520937 Human Unigene: 287228 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码的蛋白质是集落刺激因子2异二聚体受体的α亚单位,集落刺激因子2是一种控制粒细胞和巨噬细胞的产生、分化和功能的细胞因子。编码的蛋白质是受体的细胞因子家族的成员。该基因存在于X染色体和Y染色体的假常染色体区(PAR)中。已发现该基因的多个转录体变异体编码不同的异构体,其中一些异构体是膜结合的,另一些是可溶的。[由RefSeq提供]。