FITC标记的DYX1C1蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的DYX1C1蛋白抗体
英文名称: Anti-DYX1C1/FITC
抗体货号: HZ-13043R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 9:00:00
详细资料:  实验方法技术资料
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诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
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电话:
021-60345367
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陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-DYX1C1/FITC Conjugated antibody

FITC标记的DYX1C1蛋白抗体

 

英文名称 Anti-DYX1C1/FITC
中文名称 FITC标记的DYX1C1蛋白抗体
别    名 Dyslexia susceptibility 1 candidate 1; Dyslexia susceptibility 1 candidate gene 1 protein; DYX1; DYX1C1; DYXC1; DYXC1_HUMAN; EKN1; FLJ37882; MGC70618; RD.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  细胞类型标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Zebrafish, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DYX1C1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The gene encoding DYX1C1 maps in the 15q21 region, which is disrupted by a translocation t(2;15)(q11;q21) and segregates with dyslexia. Two sequence changes in DYX1C1, including one involving the translation initiation sequence and an Elk-1 transcription factor binding site (-3G --> A) and a codon (1249G --> T), introduce a premature stop codon and truncate the protein by 4 amino acids. DYX1C1 encodes a nuclear tetratricopeptide repeat domain protein that is dynamically regulated in brain. In human brain, DYX1C1 protein localizes to a fraction of cortical neurons and white matter glial cells. It is also expressed in lung, kidney and testis. 

Function:
Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.

Subunit:
Interacts with ESR1 and ESR2. Interacts with STUB1.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Expressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells.

DISEASE:
Defects in DYX1C1 may be a cause of susceptibility to dyslexia type 1 (DYX1) [MIM:127700]. A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. Note=A chromosomal aberration involving DYX1C1 has been found in a family affected by dyslexia. Translocation t(2;15)(q11;q21).

Similarity:
Contains 1 CS domain.
Contains 3 TPR repeats.

Database links:
UniProtKB/Swiss-Prot: Q8WXU2.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

编码DYX1C1的基因位于15q21区,该基因被易位t(2;15)(q11;q21)破坏,并与阅读障碍分离。DYX1C1的两个序列改变,包括翻译起始序列和Elk-1转录因子结合位点(-3G->A)以及密码子(1249G->T),引入一个过早终止密码子,并截断该蛋白质4个氨基酸。DYX1C1编码在大脑中动态调节的核四肽重复结构域蛋白。在人脑中,Dyx1C1蛋白定位为皮质神经元和白质神经胶质细胞的一小部分。它也表达在肺,肾和睾丸。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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