FITC标记的酶动力蛋白1抗体上海沪震实业有限公司

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产品名称: FITC标记的酶动力蛋白1抗体
英文名称: Anti-Dynamin 1/FITC
抗体货号: HZ-13038R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 9:05:00
详细资料:  实验方法技术资料
浏览人数:9
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
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邮编:
200612
电话:
021-60345367
传真:
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联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-Dynamin 1/FITC Conjugated antibody

FITC标记的酶动力蛋白1抗体

 

英文名称 Anti-Dynamin 1/FITC
中文名称 FITC标记的酶动力蛋白1抗体
别    名 B dynamin; D100; DNM 1; DNM; DNM1; DYN1_HUMAN; Dynamin; Dynamin-1; Dynamin1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  转运蛋白  细胞类型标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 97kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Dynamin 1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Dynamin I is a GTPase enzyme required for the retrieval of synaptic vesicles after exocytosis and functions in endocytosis by stimulating assembly of invaginating synaptic vesicles (1). Dynamin I is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C (PKC) (2–5). The phosphorylation site in PKC-phosphorylated Dynamin I is a single site at Serine 795, which is located near a binding site for the SH3 domain of p85, the regulatory subunit of phosphatidylinositol 3-kinase (2–5). Dephosphorylation is required for synaptic vesicle retrieval, suggesting that phosphorylation affects the subcellular localization of Dynamin I (5). Mouse, rat and human Dynamin I are phosphorylated on serine residues, including Ser 778, by Cdk5, regulating PACSIN1 recruitment and enabling synaptic vesicle endocytosis. 

Function:
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.

Subunit:
Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain).

Subcellular Location:
Cytoplasm; Cytoplasm; cytoskeleton; Microtubule-associated.

Similarity:
Belongs to the dynamin family.
Contains 1 GED domain.
Contains 1 PH domain.

Database links:

Entrez Gene: 1759 Human

Entrez Gene: 13429 Mouse

Entrez Gene: 140694 Rat

Omim: 602377 Human

SwissProt: Q05193 Human

SwissProt: P39053 Mouse

SwissProt: P21575 Rat

Unigene: 522413 Human

Unigene: 44736 Mouse

Unigene: 10354 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

Dynamin I是一种GTP酶,在胞吐后恢复突触小泡,并通过刺激内陷突触小泡的组装在胞吞过程中起作用(1)。Dynamin I在神经末梢中通过蛋白激酶C(PKC)(2-5)在胞浆室和体外被***酸化。PKC-***酸化Dynamin I的***酸化位点是丝氨酸795的一个位点,位于p85的SH3结构域的结合位点附近,p85是***脂酰肌醇3-激酶(2-5)的调节亚基。突触囊泡提取需要脱***酸化,表明***酸化影响Dynamin I(5)的亚细胞定位。小鼠、大鼠和人Dynamin I被Cdk5***酸化在丝氨酸残基上,包括Ser 778,调节PACSIN1募集和使突触囊泡内吞。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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