FITC标记的EMSY蛋白抗体
产品名称： FITC标记的EMSY蛋白抗体
英文名称： Anti-EMSY/FITC
产品编号： HZ-13069R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-EMSY/FITC Conjugated antibody
FITC标记的EMSY蛋白抗体
| 英文名称 | Anti-EMSY/FITC |
| 中文名称 | FITC标记的EMSY蛋白抗体 |
| 别 名 | C11orf30; Chromosome 11 open reading frame 30; EMSY protein; FLJ90741; GL002; Protein EMSY; EMSY_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 141kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EMSY |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: EMSY binds BRCA2 within a region (exon 3) deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2 exon 3, associates with chromatin regulators HP1 and BS69, and localizes to sites of repair following DNA damage. Its levels are amplified in breast and ovarian cancer. Function: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Subunit: Homodimer. Interacts with the transactivation domain of BRCA2. Interacts with the chromoshadow domain of CBX1 and with ZMYND11. Does not interact with CBX3 or CBX5. Subcellular Location: Nuclear. Localizes to DNA damage markers in irradiated cells; suggesting that it participates in the DNA repair process. Similarity: Contains 1 ENT (EMSY N-terminal) domain. Database links: UniProtKB/Swiss-Prot: Q7Z589.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
益美鲜binds BRCA2在一区（外显子3）在癌细胞中删除。如果沉默是研究《益美鲜活化电位与BRCA2基因的第3外显子（HP1染色质调节，和BS69和追踪到修复DNA损伤位点介导的。它的水平在乳腺癌和卵巢癌在法国。