FITC标记的血清反应因子辅助蛋白1抗体
产品名称： FITC标记的血清反应因子辅助蛋白1抗体
英文名称： Anti-ELK4/FITC
产品编号： HZ-13067R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-ELK4/FITC Conjugated antibody
FITC标记的血清反应因子辅助蛋白1抗体
| 英文名称 | Anti-ELK4/FITC |
| 中文名称 | FITC标记的血清反应因子辅助蛋白1抗体 |
| 别 名 | Elk4; ELK4_HUMAN; ETS domain containing protein Elk4; ETS domain protein; ETS domain-containing protein Elk-4; SAP-1; SAP1; Serum response factor accessory protein 1; SRF accessory protein 1; TCF1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 47kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ELK4/SAP-1a |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF-binding sites are also constitutive promoter elements in many muscle-specific promoters. At the c-Fos SRE, formation of a ternary complex containing SRF and its accessory protein p62TCF appears to be important for signal transduction. Two related Ets domain proteins, Elk-1 and SRF accessory protein-1 (SAP-1), have DNA binding properties identical to that of p62TCF. Elk-1 and SAP-1 contain two homologous regions of which the two amino terminal regions, the Ets domain (box A) and the B box, mediate ternary complex formation with SRF. The third homologous region, the C box located toward the C-terminus of the proteins, contains conserved consensus phosphorylation sites for MAP kinases. Function: Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. Subunit: Interacts with SIRT7. Subcellular Location: Nucleus. Similarity: Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Database links: Entrez Gene: 2005 Human Entrez Gene: 13714 Mouse Omim: 600246 Human SwissProt: P28324 Human SwissProt: Q6GSJ2 Human SwissProt: P41158 Mouse Unigene: 497520 Human Unigene: 602654 Human Unigene: 254233 Mouse Unigene: 482266 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
血清反应因子（SRF）是结合血清反应元件（SRE）的转录因子，该序列介导许多细胞基因对生长刺激的瞬时反应。SRF结合位点也是许多肌肉特异性启动子的组成性启动子元件。在c-Fos SRE中，含有SRF及其辅助蛋白p62TCF的三元复合物的形成对于信号转导是重要的。两个相关的Ets结构域蛋白Elk-1和SRF辅助蛋白-1(SAP-1)具有与p62TCF相同的DNA结合特性。Elk-1和SAP-1包含两个同源区，其中Ets结构域（框A）和B框这两个氨基末端区介导了SRF与三元络合物的形成。第三个同源区，位于蛋白质C末端的C盒，包含MAP激酶保守的一致磷酸化位点。