FITC标记的真核翻译起始因子1抗体
产品名称： FITC标记的真核翻译起始因子1抗体
英文名称： Anti-eIF1/FITC
产品编号： HZ-13066R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-eIF1/FITC Conjugated antibody
FITC标记的真核翻译起始因子1抗体
| 英文名称 | Anti-eIF1/FITC |
| 中文名称 | FITC标记的真核翻译起始因子1抗体 |
| 别 名 | A121; eIF1; EIF1_HUMAN; EIF1A; Eukaryotic translation initiation factor 1; ISO1; Protein translation factor SUI1 homolog; SUI1; Sui1iso1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 13kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human eIF1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: In mammalian cells, translation is controlled at the level of polypeptide chain initiation by initiation factors. Eukaryotic translation initiation factor 1 (eIF1) is crucial for the scanning process in vitro. During the scanning process, eIF1 is a component of a complex involved in recognition of the initiator codon. Translation is also initiated by the role of eIF1 in regulating the activity of ribosomal subunits 43S, 48S and 40S. eIF1 enables 43S ribosomal complexes to discern between cognate and near-cognate initiation codons, sensing the nucleotide content of initiation codons. It is also a promotor, along with eukar-yotic translation initiation factor 1A (eIF1A), for assembly of 48S ribosomal complexes at the initiation codon of a conventional capped mRNA. In addition, eIF1 and eIF1A, together with eukaryotic translation initiation factor 5 (eIF5), function in the formation of stable 40S ribosomal preinitiation complexes. Function: Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA. Subunit: Interacts with RENT2. Similarity: Belongs to the SUI1 family. Database links: UniProtKB/Swiss-Prot: P41567.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
在哺乳动物细胞中，翻译受起始因子的多肽链起始水平控制。真核翻译起始因子1（EIF1）是体外扫描过程的关键。在扫描过程中，EIF1是参与起始密码子识别的复合物的一个组成部分。eIF1在调节核糖体亚基43S、48S和40S的活性方面也起作用，eIF1使43S核糖体复合物能够区分同源和近同源起始密码子，检测起始密码子的核苷酸含量。它也是一个启动子，连同真核生物翻译起始因子1A（eIF1A），以组装48S核糖体复合体在起始密码子的常规封顶mRNA。此外，eIF1和eIF1A与真核翻译起始因子5（eIF5）一起参与稳定40S核糖体预起始复合物的形成。