FITC标记的磷酸化红细胞生成素受体抗体-抗体-抗体-生物在线
FITC标记的磷酸化红细胞生成素受体抗体

FITC标记的磷酸化红细胞生成素受体抗体

商家询价

产品名称: FITC标记的磷酸化红细胞生成素受体抗体

英文名称: Anti-phospho-EPO Receptor (Tyr368)/FITC

产品编号: HZ-13087R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

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  • 所在区域 : 上海
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 Rabbit Anti-phospho-EPO Receptor (Tyr368)/FITC Conjugated antibody

FITC标记的磷酸化红细胞生成素受体抗体

 

英文名称 Anti-phospho-EPO Receptor (Tyr368)/FITC
中文名称 FITC标记的磷酸化红细胞生成素受体抗体
别    名 EPO Receptor (phospho Y368); p-EPO Receptor (phospho Y368); EPOR (phospho Y368); p-EPOR (phospho Y368); erythropoietin receptor; EPO R; EPO Receptor; Erythropoietin receptor precursor; EPOR_HUMAN; MGC138358.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 肿瘤  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human EPO Receptor around the phosphorylation site of Tyr368
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.

Function:
Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein APS, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3, CRKL. Interacts with INPP5D/SHIP1. The N-terminal SH2 domain of PTPN6 binds Tyr-454 and inhibits signaling through dephosphorylation of JAK2. APS binding also inhibits the JAK-STAT signaling. Binding to PTPN11, preferentially through the N-terminal SH2 domain, promotes mitogenesis and phosphorylation of PTPN11. Binding of JAK2 (through its N-terminal) promotes cell-surface expression. Interaction with the ubiquitin ligase NOSIP mediates EPO-induced cell proliferation. Interacts with ATXN2L.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. 
Isoform EPOR-S: Secreted. Note=Secreted and located to the cell surface.

Tissue Specificity:
Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells.

Similarity:
Belongs to the type I cytokine receptor family. 
Type 1 subfamily. Contains 1 fibronectin type-III domain.

Database links:

Entrez Gene: 2057 Human

Entrez Gene: 13857 Mouse

Entrez Gene: 24336 Rat

Omim: 133171 Human

SwissProt: P19235 Human

SwissProt: P14753 Mouse

SwissProt: Q07303 Rat

Unigene: 631624 Human

Unigene: 2653 Mouse

Unigene: 22394 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

促红细胞生成素受体(EPOR)是细胞因子受体家族的成员。有几种异构体包括:EPOR -F(全长)、EPOR-S(可溶形式)和EPOR -T(截断形式)。当促红细胞生成素(EPO)结合时,EPOR激活Jak2酪氨酸激酶,该激酶激活不同的细胞内途径,包括:Ras/MAP激酶、磷脂酰肌醇3-激酶和STAT转录因子。受刺激的EPOR似乎在红系细胞存活中起作用。EPOR中的缺陷可引起红白血病和家族性红细胞增多症。在心血管系统(包括内皮细胞和心肌细胞)中发现功能性EPOR,数据表明EPO/EPO受体系统在心脏功能中起重要作用。在动物研究中,在心脏缺血/再灌注期间使用EPO治疗已显示出限制梗塞大小和凋亡的程度。