FITC标记的核苷转运蛋白ENT1抗体上海沪震实业有限公司

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产品名称: FITC标记的核苷转运蛋白ENT1抗体
英文名称: Anti-ENT1/FITC
抗体货号: HZ-13077R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 9:53:00
详细资料:  实验方法技术资料
浏览人数:5
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-ENT1/FITC Conjugated antibody

FITC标记的核苷转运蛋白ENT1抗体

 

英文名称 Anti-ENT1/FITC
中文名称 FITC标记的核苷转运蛋白ENT1抗体
别    名 Equilibrative NBMPR-sensitive nucleoside transporter; equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter; Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative nucleoside transporter 1; es-type; MGC1465; MGC3778; Nucleoside transporter; Nucleoside transporter, es-type; OTTHUMP00000016506; OTTHUMP00000016507; OTTHUMP00000016508; OTTHUMP00000016509; OTTHUMP00000016510; OTTHUMP00000016511; OTTHUMP00000016512; S29A1_HUMAN; SLC29A1; solute carrier family 29 (nucleoside transporters), member 1; Solute carrier family 29 member 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Sheep, Cynomolgus Monkey, Orangutan
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ENT1/SLC29A1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Equilibrative nucleoside transporters (ENTs) regulate many physiological processes and are widely distributed in mammals, plants, yeasts, insects, nematodes and protozoans. They enable facilitated diffusion of hydrophilic nucleosides, such as adenosine and nucleoside analogs, across cell membranes. ENTs are required for uptake of antiviral and anticancer nucleoside drugs and influence a variety of physiological processes, such as neurotransmission and platelet aggregation, by regulating the amount of adenoside available to cell surface receptors. Equilibrative nucleoside transporter 1 (ENT1), also designated solute carrier family 29 (nucleoside transporters), member 1, belongs to the SLC29A transporter family and is a mammalian ENT isoform. ENT1, along with ENT3, mediates the majority of influx and efflux of nucleosides across the plasma membrane.

Function:
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).

Subcellular Location:
Basolateral cell membrane. Apical cell membrane. Predominantly localized in the basolateral membrane in polarised MDCK cells.

Tissue Specificity:
Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen.

Post-translational modifications:
Glycosylated.

Similarity:
Belongs to the SLC29A transporter family.

Database links:

Entrez Gene: 2030 Human

Entrez Gene: 63959 Mouse

Omim: 602193 Human

SwissProt: Q99808 Human

SwissProt: Q9JIM1 Mouse

Unigene: 25450 Human

Unigene: 29744 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

平衡核苷转运体(ENT)调节许多生理过程,广泛分布于哺乳动物、植物、酵母、昆虫、线虫和原生动物中。它们能够促进亲水核苷(如腺苷和核苷类似物)在细胞膜上的扩散。ENT是摄取抗病毒和抗癌核苷药物所必需的,通过调节细胞表面受体可获得的腺苷的量而影响各种生理过程,如神经传递和血小板聚集。平衡核苷转运体1(ENT1),也称为溶质载体家族29(核苷转运体),成员1,属于SLC29A转运体家族,是哺乳动物耳鼻喉科的同型体。EtT1与Et3一起介导核膜在质膜上的大部分流入和流出。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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