FITC标记的磷酸酶/磷酸二酯酶家族成员6抗体
产品名称： FITC标记的磷酸酶/磷酸二酯酶家族成员6抗体
英文名称： Anti-ENPP6/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-ENPP6/FITC Conjugated antibody
FITC标记的磷酸酶/磷酸二酯酶家族成员6抗体
| 英文名称 | Anti-ENPP6/FITC |
| 中文名称 | FITC标记的磷酸酶/磷酸二酯酶家族成员6抗体 |
| 别 名 | B830047L21Rik; E-NPP 6; Ectonucleotide pyrophosphatase/phosphodiesterase 6; ectonucleotide pyrophosphatase/phosphodiesterase family member 6; ENPP 6; NPP 6; NPP6; ENPP6_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 激酶和磷酸酶 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ENPP6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: NPP6 is a 440 amino acid member of the nucleotide pyrophosphatase/phosphodiesterase family. NPP6 is a secreted and single-pass type I membrane protein. Predominantly expressed in brain and kidney, NPP6 is a choline-specific glycerophosphodiester phosphodiesterase. NPP6 can hydrolyze the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, glycerophosphorylcholine, sphingosylphosphorylcholine and lysophosphatidylcholine (LPC). NPP6 has been found to have a preference for LPC with polyunsaturated or short fatty acids. The gene encoding NPP6 maps to human chromosome 4, which consists of approximately 6% of the human genome and nearly 900 genes. Chromosome 4 is associated with Huntington's disease, FGFR-3, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Function: ENPP6 is a choline-specific glycerophosphodiester phosphodiesterase, which hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5 prime-monophosphate. It hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. ENPP6 has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. ENPP6 also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. ENPP6 is predominantly expressed in kidney and brain. Subunit: Homodimer; disulfide-linked. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Secreted. Note: A minor secreted form also exists. Tissue Specificity: Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level). Similarity: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. Database links: Entrez Gene: 133121 Human Entrez Gene: 320981 Mouse Entrez Gene: 306460 Rat SwissProt: Q6UWR7 Human SwissProt: Q8BGN3 Mouse SwissProt: B0BND0 Rat Unigene: 297814 Human Unigene: 211429 Mouse Unigene: 8484 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NPP6是核苷酸焦磷酸酶/磷酸二酯酶家族的440氨基酸成员。NPP6是分泌型单通道I型膜蛋白。NPP6主要在脑和肾中表达，是胆碱特异性的甘油磷酸二酯磷酸二酯酶。NPP6可水解磷脂酶C、对基磷酰胆碱、甘油磷酰胆碱、鞘氨醇磷酰胆碱和溶血磷脂酰胆碱（LPC）等经典底物。NPP6已被发现具有多不饱和脂肪酸或短脂肪酸的LPC的偏好。编码NPP6的基因定位于人类4号染色体，由约6%的人类基因组和近900个基因组成。染色体4与亨廷顿病、FGFR-3、Ellis-van Creveld综合征、甲基丙二酸血症和多囊肾病有关。