FITC标记的磷酸酶/磷酸二酯酶家族成员6抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸酶/磷酸二酯酶家族成员6抗体
英文名称: Anti-ENPP6/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 9:54:00
详细资料:  实验方法技术资料
浏览人数:11
诚信指数:962点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
200612
电话:
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传真:
021-31320307
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上海·中国-上海
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产品详细描述

 Rabbit Anti-ENPP6/FITC Conjugated antibody

FITC标记的***酸酶/***酸二酯酶家族成员6抗体

 

英文名称 Anti-ENPP6/FITC
中文名称 FITC标记的***酸酶/***酸二酯酶家族成员6抗体
别    名 B830047L21Rik; E-NPP 6; Ectonucleotide pyrophosphatase/phosphodiesterase 6; ectonucleotide pyrophosphatase/phosphodiesterase family member 6; ENPP 6; NPP 6; NPP6; ENPP6_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  神经生物学  激酶和***酸酶  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ENPP6
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
NPP6 is a 440 amino acid member of the nucleotide pyrophosphatase/phosphodiesterase family. NPP6 is a secreted and single-pass type I membrane protein. Predominantly expressed in brain and kidney, NPP6 is a choline-specific glycerophosphodiester phosphodiesterase. NPP6 can hydrolyze the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, glycerophosphorylcholine, sphingosylphosphorylcholine and lysophosphatidylcholine (LPC). NPP6 has been found to have a preference for LPC with polyunsaturated or short fatty acids. The gene encoding NPP6 maps to human chromosome 4, which consists of approximately 6% of the human genome and nearly 900 genes. Chromosome 4 is associated with Huntington's disease, FGFR-3, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.

Function:
ENPP6 is a choline-specific glycerophosphodiester phosphodiesterase, which hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5 prime-monophosphate. It hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. ENPP6 has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. ENPP6 also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. ENPP6 is predominantly expressed in kidney and brain.

Subunit:
Homodimer; disulfide-linked.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Secreted. Note: A minor secreted form also exists.

Tissue Specificity:
Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level).

Similarity:
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Database links:

Entrez Gene: 133121 Human

Entrez Gene: 320981 Mouse

Entrez Gene: 306460 Rat

SwissProt: Q6UWR7 Human

SwissProt: Q8BGN3 Mouse

SwissProt: B0BND0 Rat

Unigene: 297814 Human

Unigene: 211429 Mouse

Unigene: 8484 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

NPP6是核苷酸焦***酸酶/***酸二酯酶家族的440氨基酸成员。NPP6是分泌型单通道I型膜蛋白。NPP6主要在脑和肾中表达,是胆碱特异性的甘油***酸二酯***酸二酯酶。NPP6可水解***脂酶C、对基***酰胆碱、甘油***酰胆碱、鞘氨醇***酰胆碱和溶血***脂酰胆碱(LPC)等经典底物。NPP6已被发现具有多不饱和脂肪酸或短脂肪酸的LPC的偏好。编码NPP6的基因定位于人类4号染色体,由约6%的人类基因组和近900个基因组成。染色体4与亨廷顿病、FGFR-3、Ellis-van Creveld综合征、甲基丙二酸血症和多囊肾病有关。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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