FITC标记的烯醇化酶超家族成员1抗体
产品名称： FITC标记的烯醇化酶超家族成员1抗体
英文名称： Anti-ENOSF1/FITC
产品编号： HZ-13070R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ENOSF1/FITC Conjugated antibody
FITC标记的烯醇化酶超家族成员1抗体
| 英文名称 | Anti-ENOSF1/FITC |
| 中文名称 | FITC标记的烯醇化酶超家族成员1抗体 |
| 别 名 | Enolase superfamily member 1; ENOSF 1; HSRTSBETA; RTS alpha; RTS; RTS beta; RTS beta protein; TYMSAS; |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Dog, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ENOSF1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The rTS gene codes for a naturally occurring antisense RNA to thymidylate synthase (TS) mRNA and two proteins (rTSalpha and rTSbeta (also known as ENOSF1)). The role of the major protein product of rTS, ENOSF1 has been linked to alterations in TS protein expression, but the precise function of ENOSF1 is unknown. Expression of rTS is associated with growth arrest in cell culture, but its overexpression has been noted in cells resistant to anticancer drugs such as 5-fluorouracil and methotrexate. Studies have shown that increased expression of ENOSF1 is associated with the decrease in TS protein expression due to production of novel, diffusible signal molecules. Function: May regulate thymidylate synthase activity. Subcellular Location: Mitochondrial. Post-translational modifications: Could be sumoylated. Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. ENOSF1 subfamily. Database links: UniProtKB/Swiss-Prot: Q7L5Y1.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
rTS基因编码天然存在的胸苷酸合成酶(TS)反义RNA mRNA和两种蛋白(rTSα和rTSbeta(也称为ENOSF1))。RTS的主要蛋白产物ENOSF1的作用与TS蛋白表达的改变有关，但ENOSF1的精确功能尚不清楚。rTS的表达与细胞培养中的生长停滞有关，但在抗癌药物如5-氟尿嘧啶和甲氨喋呤的细胞中已经发现其过表达。研究表明，ENOSF1表达增加与TS蛋白表达减少有关，因为产生新的、可扩散的信号分子。