FITC标记的内质网蛋白ERp72抗体上海沪震实业有限公司

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产品名称: FITC标记的内质网蛋白ERp72抗体
英文名称: Anti-ERp72/FITC
抗体货号: HZ-13106R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 10:02:00
详细资料:  实验方法技术资料
浏览人数:5
诚信指数:962点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
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邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-ERp72/FITC Conjugated antibody

FITC标记的内质网蛋白ERp72抗体

 

英文名称 Anti-ERp72/FITC
中文名称 FITC标记的内质网蛋白ERp72抗体
别    名 Calcium binding protein intestinal related; Endoplasmic reticulum resident protein 70; Endoplasmic reticulum resident protein 72; ER protein 70; ER protein 72; ERP 70; ERp 72; ERp-72; ERP70; ERp72; PDIA 4; PDIA4; PDIA4_HUMAN; PDIR; Protein disulfide isomerase A4; Protein disulfide isomerase associated 4; Protein disulfide isomerase family A member 4; Protein disulfide isomerase related protein; Protein disulfide-isomerase A4; Protein ERp 72; Protein ERp72.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Rabbit, Sheep, Monkey, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ERp72
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Mammals defend themselves against intracellular pathogens through presentation of cytoplasmically derived short pathogenic peptides to the cell surface of cytotoxic T lymphocytes, which subsequently leads to cytotoxic events with respect to the affected cell. Antigen presentation is mediated by major histocompatibility complex (MHC) class I molecules, which bind and coordinate short pathogenic peptides. The proper folding and assembly of MHC class I molecules in the endoplasmic reticulum (ER) involve a number of components. MHC class I molecules assemble in the ER with chaperones before binding to the transporter associated with antigen processing (TAP) protein. ERp57 is a component of the MHC class I pathway that appears to interact with MHC class I molecules before they associate with TAP. ERp72, also designated protein disulfide-isomerase A4, is involved in the catalysis of protein -S-S- bond rearrangement. ERp57 and ERp72 may act as proteases, protein disulfide isomerases, phospholipases or a combination of these.

Subunit:
Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Subcellular Location:
Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Similarity:
Belongs to the protein disulfide isomerase family.
Contains 3 thioredoxin domains.

Database links:

Entrez Gene: 415110 Cow

Entrez Gene: 9601 Human

Entrez Gene: 12304 Mouse

Entrez Gene: 116598 Rat

SwissProt: Q29RV1 Cow

SwissProt: P13667 Human

SwissProt: P08003 Mouse

SwissProt: P38659 Rat

Unigene: 93659 Human

Unigene: 2442 Mouse

Unigene: 39305 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

哺乳动物通过向细胞毒性T淋巴细胞的细胞表面呈递细胞质衍生的短致病性肽来抵御细胞内病原体,这随后导致与受影响细胞有关的细胞毒性事件。抗原呈递由主要组织相容性复合物(MHC)I类分子介导,它们结合和协调短致病性肽。适当的折叠和组装MHC I类分子在内质网(ER)涉及多个组成部分。MHC I类分子在结合到与抗原处理(TAP)蛋白相关的转运体之前与伴侣在ER中聚集。ERp57是MHC I类通路的组成部分,在MHC I类分子与TAP结合之前,它们似乎与MHC I类分子相互作用。Erp72也被称为蛋白二硫键异构酶A4,参与了蛋白质-S—S键重排的催化作用。Erp57和Erp72可作为蛋白酶、蛋白质二硫键异构酶、***脂酶或它们的组合。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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