Rabbit Anti-ERp72/FITC Conjugated antibody
|别 名||Calcium binding protein intestinal related; Endoplasmic reticulum resident protein 70; Endoplasmic reticulum resident protein 72; ER protein 70; ER protein 72; ERP 70; ERp 72; ERp-72; ERP70; ERp72; PDIA 4; PDIA4; PDIA4_HUMAN; PDIR; Protein disulfide isomerase A4; Protein disulfide isomerase associated 4; Protein disulfide isomerase family A member 4; Protein disulfide isomerase related protein; Protein disulfide-isomerase A4; Protein ERp 72; Protein ERp72.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 信号转导|
|交叉反应||Human, Mouse, Rat, Cow, Rabbit, Sheep, Monkey,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||71kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human ERp72|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Mammals defend themselves against intracellular pathogens through presentation of cytoplasmically derived short pathogenic peptides to the cell surface of cytotoxic T lymphocytes, which subsequently leads to cytotoxic events with respect to the affected cell. Antigen presentation is mediated by major histocompatibility complex (MHC) class I molecules, which bind and coordinate short pathogenic peptides. The proper folding and assembly of MHC class I molecules in the endoplasmic reticulum (ER) involve a number of components. MHC class I molecules assemble in the ER with chaperones before binding to the transporter associated with antigen processing (TAP) protein. ERp57 is a component of the MHC class I pathway that appears to interact with MHC class I molecules before they associate with TAP. ERp72, also designated protein disulfide-isomerase A4, is involved in the catalysis of protein -S-S- bond rearrangement. ERp57 and ERp72 may act as proteases, protein disulfide isomerases, phospholipases or a combination of these.
Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Belongs to the protein disulfide isomerase family.
Contains 3 thioredoxin domains.
Entrez Gene: 415110 Cow
Entrez Gene: 9601 Human
Entrez Gene: 12304 Mouse
Entrez Gene: 116598 Rat
SwissProt: Q29RV1 Cow
SwissProt: P13667 Human
SwissProt: P08003 Mouse
SwissProt: P38659 Rat
Unigene: 93659 Human
Unigene: 2442 Mouse
Unigene: 39305 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
哺乳动物通过向细胞毒性T淋巴细胞的细胞表面呈递细胞质衍生的短致病性肽来抵御细胞内病原体，这随后导致与受影响细胞有关的细胞毒性事件。抗原呈递由主要组织相容性复合物（MHC）I类分子介导，它们结合和协调短致病性肽。适当的折叠和组装MHC I类分子在内质网（ER）涉及多个组成部分。MHC I类分子在结合到与抗原处理（TAP）蛋白相关的转运体之前与伴侣在ER中聚集。ERp57是MHC I类通路的组成部分，在MHC I类分子与TAP结合之前，它们似乎与MHC I类分子相互作用。Erp72也被称为蛋白二硫键异构酶A4，参与了蛋白质-S—S键重排的催化作用。Erp57和Erp72可作为蛋白酶、蛋白质二硫键异构酶、***脂酶或它们的组合。