Rabbit Anti-Epsin 2/FITC Conjugated antibody
|别 名||EHB21; EPN 2; EPN-2; Epn2; EPN2_HUMAN; EPS 15 interacting protein 2; EPS-15-interacting protein 2; Eps15 binding protein; Epsin 2; Epsin-2; Epsin2; KIAA1065; OTTHUMP00000065808; OTTHUMP00000065809; OTTHUMP00000065810; OTTHUMP00000065811; OTTHUMP00000065889.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 生长因子和*** 转录调节因子 激酶和***酸酶|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||69kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human Epsin 2|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation. Miscues in RTK signaling pathways can result in cellular transformation and ultimately in cancer. Two novel EGF receptor substrates have been described, designated EGF-receptor pathway substrates 8 and 15, or Eps8 and Eps15. Epsin is a binding partner to Eps15. Both epsin and Eps15 have an ubiquitous tissue distribution but are concentrated in presynaptic nerve terminals specialized for the Clathrin-mediated endocytosis of synaptic vesicles. Disruption of epsin function blocks Clathrin-mediated endocytosis. Epsin, along with its binding partner Eps15, is proposed to be involved in the assistance of Clathrin coat rearrangement during Clathrin coated pit invagination. Epsin 2a, and 2b are splicing variants of epsin 2, which is associated with Clathrin-mediated endocytosis and are enriched in the brain in the peri-Golgi region.
Plays a role in the formation of clathrin-coated invaginations and endocytosis.
Binds EPS15 (By similarity). Binds AP-2 and clathrin.
Cytoplasm. Cytoplasmic vesicle; clathrin-coated vesicle. In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.
Highest expression is found in brain. Detected at lower levels in lung and liver.
Belongs to the epsin family.
Contains 1 ENTH (epsin N-terminal homology) domain.
Contains 2 UIM (ubiquitin-interacting motif) repeats.
Entrez Gene: 22905 Human
Entrez Gene: 13855 Mouse
Entrez Gene: 60443 Rat
Omim: 607263 Human
SwissProt: O95208 Human
SwissProt: Q8CHU3 Mouse
SwissProt: Q9Z1Z3 Rat
Unigene: 309467 Human
Unigene: 139695 Mouse
Unigene: 436466 Mouse
Unigene: 44273 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
阐明受体酪氨酸激酶（RTKs）调节细胞生理学以响应刺激的机制对于理解生长调节是至关重要的。RTK信号通路中的错误可能导致细胞转化，最终导致癌症。已经描述了两种新的EGF受体底物，其命名为EGF受体途径底物8和15，或EPS8和EPS15。Epsin是EPS15的有约束力的合作伙伴。epsin和Eps15都具有普遍的组织分布，但都集中在突触前神经末梢，这些神经末梢专门用于Clathrin介导的突触小泡的内吞作用。干扰素功能块阻断网格蛋白介导的内吞作用。Epsin及其结合伴侣Eps15被提议参与在Clathrin涂层凹坑内陷期间协助Clathrin涂层重排。Epsin 2a和2b是epsin 2的剪接变异体，与Clathrin介导的内吞作用有关，并富集于高尔基体周围区域的脑内。