FITC标记的表皮生长因子受体底物15抗体
产品名称： FITC标记的表皮生长因子受体底物15抗体
英文名称： Anti-EPS15R/FITC
产品编号： HZ-13100R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
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- 邮编 : 200612
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Rabbit Anti-EPS15R/FITC Conjugated antibody
FITC标记的表皮生长因子受体底物15抗体
| 英文名称 | Anti-EPS15R/FITC |
| 中文名称 | FITC标记的表皮生长因子受体底物15抗体 |
| 别 名 | epidermal growth factor receptor pathway substrate 15- ike 1; Epidermal growth factor receptor substrate 15 like 1; epidermal growth factor receptor substrate EPS15R; Eps15 related protein; eps15R;EP15R_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 生长因子和激素 激酶和磷酸酶 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 94kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EPS15R |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation, as miscues in RTK signaling can result in cellular transformation events that may ultimately lead to cancer. Eps15 (EGF-receptor pathway substrate 15) is an EGF receptor substrate that become become tyrosine phosphorylated subsequent to EGF stimulation. Over expression of Eps15 in NIH/3T3 cells causes cellular transformation, implying involvement of Eps15 in the regulation of cell proliferation. Eps15R (Eps15-related), also known as Eps15L1 (epidermal growth factor receptor substrate 15-like 1), is an 864 amino acid protein that contains one EF-hand domain and three EH domains. Localized to a variety of places within the cell, including the nucleus, cytoplasm and membrane-coated pits, Eps15R is thought to function as a component of clathrin-coated pits. Like Eps15, Eps15R may play an important role in receptor-mediated endocytosis. Function: EPS15 and EPS15R are substrates of the epidermal growth factor (EGF) receptor kinase, which are characterized by their ability to bind to the clathrin adaptor protein complex adaptor protein 2, and the presence of a protein:protein interaction domain, the EH domain. Evidence suggests that EPS15 and EPS15R are involved in endocytosis. The major difference between these two related proteins is that EPS15R is also found in the nucleus, whereas EPS15 is excluded from this compartment at steady state. Subunit: Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2) (By similarity). Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2. Subcellular Location: Cell Membrane and Nuclear. Post-translational modifications: Phosphorylated on tyrosine residues by EGFR (By similarity). Similarity: Contains 1 EF-hand domain. Contains 3 EH domains. Database links: UniProtKB/Swiss-Prot: Q9UBC2.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
阐明受体酪氨酸激酶（RTK）调节细胞生理以响应刺激的机制对于理解生长调节是至关重要的，因为RTK信号传导中的错误信号可导致最终可能导致癌症的细胞转化事件。Eps15(EGF受体途径底物15)是EGF受体底物，在EGF刺激后变成酪氨酸磷酸化。EPs15在NIH/3T3细胞中的过度表达导致细胞转化，表明EPs15参与细胞增殖的调节。Eps15R(Eps15-.)，又称Eps15L1(表皮生长因子受体底物15-like 1)，是一种864个氨基酸的蛋白质，含有一个EF-hand结构域和三个EH结构域。Eps15R定位于细胞内的多种部位，包括细胞核、细胞质和膜包被的凹坑，被认为是包涵体包被的凹坑的组成部分。与EPS15一样，EPS15R在受体介导的内吞作用中起重要作用。