Rabbit Anti-ERF/FITC Conjugated antibody
|别 名||ERF; ERF_HUMAN; ETS domain containing transcription factor ERF; ETS domain-containing transcription factor ERF; Ets2 repressor factor; PE 2; PE-2; PE2.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 转录调节因子 表观遗传学|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||59kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human ERF/Ets2 Repressor Factor|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
ABT1 (activator of basal transcription 1) is a nuclear protein that associates with the TATA-binding protein (TBP) and enhances basal transcription activity of class II promoters. ABT1 associates with TBP in HeLa nuclear extracts in vitro. Another protein, designated ERF, is a member of the Ets family of transcription factors. The members of the Ets family are grouped because they share a highly conserved DNA binding domain. These factors are involved in growth factor pathways and regulate both proliferation and differentiation. ERF (Ets-2 repressor factor) is a ubiquitously expressed Ets-domain protein that exhibits strong transcriptional repressor activity, suppresses Ets-induced transformation and is regulated by MAPK phosphorylation. ERF transcription may be regulated by Ets-domain proteins. Additionally, modulation of ERF activity is involved in the transcriptional regulation of genes activated during entry into G1 phase.
Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation.
Highest levels in testis, ovary, pancreas, and heart.
Phosphorylated by multiple kinases including MAPK1/ERK2 at THR-526.
Phosphorylation regulates the activity of ERF.
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
Entrez Gene: 2077 Human
Entrez Gene: 13875 Mouse
Entrez Gene: 292721 Rat
Omim: 611888 Human
SwissProt: P50548 Human
SwissProt: P70459 Mouse
Unigene: 655969 Human
Unigene: 8068 Mouse
Unigene: 9093 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
ABT1（基础转录激活子1）是一种与TATA结合蛋白（TBP）结合并增强II类启动子基础转录活性的核蛋白。ABT1与HeLa核提取液中的TBP相关。另一种蛋白，命名为ERF，是Ets家族转录因子的成员。Ets家族的成员被分组，因为它们共享高度保守的DNA结合结构域。这些因素参与生长因子途径，并调节增殖和分化。ERF(Ets-2repressor factor，Ets-2repressor factor)是一种广泛表达的Ets结构域蛋白，具有强烈的转录抑制活性，抑制Ets诱导的转化，并受MAPK***酸化调控。ERF转录可受ETS结构域蛋白的调控。此外，ERF活性的调节参与进入G1期激活的基因的转录调节。