FITC标记的EGF毒素受体7跨膜结构域蛋白1抗体上海沪震实业有限公司

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产品名称: FITC标记的EGF毒素受体7跨膜结构域蛋白1抗体
英文名称: Anti-ETL/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 10:22:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-ETL/FITC Conjugated antibody

FITC标记的EGF毒素受体7跨膜结构域蛋白1抗体

 

英文名称 Anti-ETL/FITC
中文名称 FITC标记的EGF毒素受体7跨膜结构域蛋白1抗体
别    名 EGF; EGF latrophilin and seven transmembrane domain containing 1; EGF TM7 latrophilin related protein; EGF-TM7-latrophilin-related protein; EGFTM7 latrophilin related protein; ELTD 1; ELTD1; ELTD1_HUMAN; ETL; ETL protein; KPG_003; latrophilin and seven transmembrane domain-containing protein 1; zgc:63629.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  G蛋白偶联受体  G蛋白信号  跨膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Horse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 76kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ETL/ELTD1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The epidermal growth factor (EGF)-TM7 family constitutes a group of leukocyte-restricted, class B G-protein coupled receptors (GPCRs). These include CD97, EMR1(EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL. These family members are characterized by an extended extracellular region with several N-terminal EGF domains and are predominantly expressed on cells of the immune system. Unlike other GPCRs, neither EMR2 nor EMR3 have mouse orthologs. The molecular twins CD97 and EMR2 only differ by 6 out of 236 amino acids, but this slight difference is enough to alter ligand specificity and confer nonredundant functions. EMR3 may function in myeloid-myeloid interactions during immune and inflammatory responses. ETL is a 738 amino acid protein composed of a large extracellular domain with EGF-like repeats, a seven-transmembrane domain, and a short cytoplasmic tail. ETL mRNA expression is up-regulated in the adult rat and human heart.

Function:
Could be involved in cardiac development.

Subunit:
Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface (By similarity).

Subcellular Location:
Cell membrane.

Tissue Specificity:
Mainly expressed in smooth muscle.

Post-translational modifications:
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.

Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 2 EGF-like domains.
Contains 1 GPS domain.

Database links:

Entrez Gene: 64123 Human

SwissProt: Q9HBW9 Human

Unigene: 132314 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

表皮生长因子(EGF)-TM7家族是一组白细胞受限的B类G蛋白偶联受体(GPCR)。这些包括CD97、EMR1(含有粘蛋白样受体1的EGF样分子,在小鼠中称为F4/80)、EMR2、EMR3、FIRE和ETL。这些家族成员的特征是具有若干N-末端EGF结构域的扩展细胞外区域,并且主要表达在免疫系统的细胞上。不像其他GPCR,EMR2和EMR3都没有小鼠直系同源物。分子孪生子CD97和EMR2在236个氨基酸中只相差6个,但是这个微小的差异足以改变配体的特异性并赋予非冗余功能。EMR3在免疫和炎症反应过程中可能在髓系髓鞘相互作用中起作用。ETL是由一个具有EGF样重复序列的大细胞外结构域、一个7跨膜结构域和一个短细胞质尾部组成的738个氨基酸蛋白。ETL mRNA在成年大鼠和人心脏中表达上调。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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