FITC标记的眼睛发育缺失蛋白EYA2抗体上海沪震实业有限公司

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产品名称: FITC标记的眼睛发育缺失蛋白EYA2抗体
英文名称: Anti-EYA2/FITC
抗体货号: HZ-13125R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 10:25:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-EYA2/FITC Conjugated antibody

FITC标记的眼睛发育缺失蛋白EYA2抗体

 

英文名称 Anti-EYA2/FITC
中文名称 FITC标记的眼睛发育缺失蛋白EYA2抗体
别    名 EAB 1; EAB1; EYA 2; EYA2; EYA2_HUMAN; eyes absent 2 homolog (Drosophila); Eyes absent homolog 2; Translation of this uORF probably lowers the translation efficiency of EYA2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  发育生物学  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EYA2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
A gene on chromosome 20q13.1 encodes Eya2 (eyes absent). EYA2 is one of four members of the eyes absent family. A 271 amino acid domain at the carboxy-terminal is highly conserved amongst the members of the eyes absent family, while the PST (proline-serive-threonin)-rich amino-terminal is highly divergent. EYA2 is expressed relatively late in development in the cytoplasm of extensor tendons and ligaments of the phalangeal elements of the limb, cranial placodes, branchial arches, central nervous system, and the developing eye. Pax3 induces the expression of Eya2 in a cascade that is necessary and sufficient for myogenesis. EYA2, like EYA1, acts as a transcriptional activator in connective tissue patterning through its PST domain, which functions as a transactivation domain. EYA2 is translocated to the nucleus by Six proteins, which interact through their domain and homeodomain with EYA2. EYA2 carboxy-terminal interacts with the G Alpha z and G Alphai 2 proteins. This interaction prevents Six proteins from translocating EYA2 to the nucleus.

Function:
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity. 

Subunit:
Interacts with GNAZ and GNAI2. Interacts with DACH2 and SIX1, and probably with SIX2, SIX4 and SIX5. Interacts with CAPN8 (By similarity). 

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.

Similarity:
Belongs to the HAD-like hydrolase superfamily. EYA family.

Database links:
UniProtKB/Swiss-Prot: O00167.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

染色体20q131的基因编码EYA2(眼睛缺失)。EYA2是无眼家族的四个成员之一。在眼缺失家族成员中,羧基末端的271个氨基酸结构域高度保守,而富含脯氨酸丝氨酸苏氨酸的氨基酸结构域高度分化。EYA2在伸肌腱和四肢指骨元素的韧带、颅骨、鳃弓、中枢神经系统和发育中的眼睛的细胞质中表达相对较晚。PAX3诱导EYA2在级联中的表达,这对于肌肉发生是必要的和充分的。EYA2与EYA1一样,通过其PST结构域在结缔组织模式化中起转录激活剂的作用,PST结构域起反式激活域的作用。EYA2通过六个蛋白转位到细胞核,通过它们的结构域和同源结构域与EYA2相互作用。EYA2羧基端与GαZ和Gα2蛋白相互作用。这种相互作用阻止了六种蛋白质从EYA2转运到细胞核。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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