FITC标记的核酸外切酶1抗体上海沪震实业有限公司

金牌供应商

性能参数

产品名称: FITC标记的核酸外切酶1抗体
英文名称: Anti-Exonuclease 1/FITC
抗体货号: HZ-13119R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 10:30:00
详细资料:  实验方法技术资料
浏览人数:7
诚信指数:962点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
点此求购
在线QQ: 我是2043711056,请问我有什么可以帮到您呢?
生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
邮件:
公司展台:
在线QQ:
我是2043711056,请问我有什么可以帮到您呢?
扫一扫,关注我们

产品详细描述

 Rabbit Anti-Exonuclease 1/FITC Conjugated antibody

FITC标记的核酸外切酶1抗体

 

英文名称 Anti-Exonuclease 1/FITC
中文名称 FITC标记的核酸外切酶1抗体
别    名 exo1; EXO1_HUMAN; ExoI; Exonuclease 1; Exonuclease I; Exonuclease1; HEX1; hExo I; hExo1; hExoI; Rad2 nuclease family member homolog of S. cerevisiae exonuclease 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chimpanzee, Macaque Monkey, Gorilla, Chinese Hamster, Orangu
产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 94kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Exonuclease 1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Comparative evaluation of the expression patterns of the human and mouse genes, combined with previous biochemical and yeast genetic studies, indicate that the Exo1 (Exonuclease I) proteins are important contributors to chromosome processing during mammalian DNA repair and recombination. In mice, the Exo1 gene maps to distal chromosome 1, consistent with the recent mapping of the orthologous human HEX1/EXO1 gene to chromosome 1q43. Exo1 is expressed prominently in testis, an area of active homologous recombination, and spleen, a prominent lymphoid tissue. In both mammalian and yeast systems, Exo1 is a 5'-3' double stranded DNA exonuclease that has previously been implicated in DNA mismatch repair (MMR). The MMR system ensures genome integrity by removing mispaired and unpaired bases that originate during replication. In humans, Exo1 interacts with MSH2 and MLH1 and has been proposed to be a redundant exonuclease in MMR. In both mammalian and yeast systems, Exo1 plays a structural role in MMR and stabilizes multiprotein complexes containing a number of MMR proteins.

Function:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.

Subunit:
Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'->3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'->5' exonuclease activity and suppress the 5'->3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'->3' exonuclease activity and cleavage of 5'-overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures.

Subcellular Location:
Nucleus. Colocalizes with PCNA to discrete nuclear foci in S-phase.

Tissue Specificity:
Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach.

Post-translational modifications:
Phosphorylated upon DNA damage and in response to agents stalling DNA replication, probably by ATM or ATR. Phosphorylation at Ser-454, Thr-621 and Ser-714 is induced upon DNA-damage caused by treatment with hydroxyurea (HU) but not upon IR treatment. The HU-induced EXO1 triple phosphorylation facilitates destabilisation/degradation of the protein.

Similarity:
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.

Database links:

Entrez Gene: 457856 Chimpanzee

Entrez Gene: 9156 Human

Entrez Gene: 305000 Rat

Omim: 606063 Human

SwissProt: Q9UQ84 Human

Unigene: 498248 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

对人和小鼠基因表达模式的比较评价,结合以前的生化和酵母遗传学研究,表明Exo1(Exonuclease I)蛋白是哺乳动物DNA修复和重组过程中染色体加工的重要贡献者。在小鼠中,Exo1基因定位到远端染色体1,这与最近将人类HEX1/EXO1基因定位到染色体1q43是一致的。EXO1在睾丸、主动同源重组的区域和脾脏、突出的淋巴组织中显著表达。在哺乳动物和酵母系统中,Exo1是一种5'-3'双链DNA外切酶,它以前与DNA错配修复(MMR)有关。MMR系统通过去除复制过程中产生的错配碱基和不成对碱基来确保基因组完整性。在人类中,EXO1与MSH2和MLH1相互作用,并已被认为是MMR中的多余核酸外切酶。在哺乳动物和酵母系统中,Exo1在MMR中起结构性作用,并且稳定含有许多MMR蛋白的多蛋白复合物。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

查看FITC标记的核酸外切酶1抗体产品的用户还对以下产品感兴趣

暂无

ADVERTISEMENT

找不到您所需的产品,发布求购试试?

标题:*
描述:
姓名:*
Email:*
单位:*
电话:*
地址:*
邮编:
资料: 需要 不需要
报价: 需要 不需要