FITC标记的跨膜通道蛋白8抗体上海沪震实业有限公司

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产品名称: FITC标记的跨膜通道蛋白8抗体
英文名称: Anti-EVER2/FITC
抗体货号: HZ-13116R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 10:33:00
详细资料:  实验方法技术资料
浏览人数:7
诚信指数:932点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-EVER2/FITC Conjugated antibody

 

FITC标记的跨膜通道蛋白8抗体
英文名称 Anti-EVER2/FITC
中文名称 FITC标记的跨膜通道蛋白8抗体
别    名 epidermodysplasia verruciformis 2; Epidermodysplasia verruciformis protein 2; EV2; EVIN2; FLJ40668; FLJ43684; MGC102701; MGC40121; TMC8; Transmembrane channel like protein 8; TMC8_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  跨膜蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EVER2/TMC8
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Transmembrane channel-like protein 8 (TMC8), also known as Epidermodysplasia verruciformis protein 2 (EVER2), is a 726 amino acid member of the TMC family of proteins. Localized to the endoplasmic reticulum membrane, TMC8 is thought to form a transmembrane channel-like protein with eight predicted transmembrane domains and three leucine zipper motifs. Mutations in the genes encoding TMC8 and TMC6, another member of the TMC family, have been shown to cause epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. Infection by HPVs lead to persistent wart-like or macular lesions. TMC8 is expressed in placenta, prostate and testis, and three named isoforms exist as a result of alternative splicing events.

Function:
Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc. At least two isoforms of EVER2 are known to exist.

Subcellular Location:
Endoplasmic reticulum membrane; Multi pass membrane protein.

Tissue Specificity:
Expressed in placenta, prostate and testis. 

DISEASE:
Defects in TMC8 are a cause of epidermodysplasia verruciformis (EV) [MIM:226400]. It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. 

Similarity:
Belongs to the TMC family. 

Database links:

Entrez Gene: 147138 Human

Entrez Gene: 217356 Mouse

Omim: 605829 Human

SwissProt: Q8IU68 Human

SwissProt: Q7TN58 Mouse

Unigene: 592102 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

 

跨膜通道样蛋白8(TMC8),又称疣状表皮发育不良蛋白2(EVER2),是TMC蛋白家族的726个氨基酸成员。TMC8定位于内质网膜,据认为形成具有八个预测跨膜结构域和三个亮氨酸拉链基序的跨膜通道样蛋白。在tmc8和tmc6编码基因的突变,对TMC家族的另一成员,已被证明会导致疣状表皮发育不良(EV),一种常染色体隐性遗传性皮肤病的特点是不正常的人类乳头瘤病毒(HPV)的易感性和进展率很高鳞状细胞暴露于皮肤的癌。HPVs感染导致顽固性疣样或黄斑病变。TMC8在胎盘、前列腺和睾丸中表达,并且三个命名的同种型存在作为选择性剪接事件的结果。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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