FITC标记的磷酸化埃兹蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化埃兹蛋白抗体
英文名称: Anti-Phospho-Ezrin (Tyr478)/FITC
抗体货号: HZ-13128R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 10:47:00
详细资料:  实验方法技术资料
浏览人数:9
诚信指数:962点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-Phospho-Ezrin (Tyr478)/FITC Conjugated antibody

 

FITC标记的***酸化埃兹蛋白抗体
英文名称 Anti-Phospho-Ezrin (Tyr478)/FITC
中文名称 FITC标记的***酸化埃兹蛋白抗体
别    名 Ezrin (phospho Y478); Ezrin (phospho Tyr478); p-Ezrin (phospho Y478); CVIL; CVL; cytovillin 2; Cytovillin; DKFZp762H157; FLJ26216; MGC1584; p81; VIL 2; VIL2; Villin 2; Villin2; EZRI_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  心血管  细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 69kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Ezrin around the phosphorylation site of Tyr478
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

Subunit:
Interacts with MPP5 and SLC9A3R2. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts with MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1 and TMEM8B. Interacts (when phosphorylated) with FES/FPS.

Subcellular Location:
Apical cell membrane. Cell projection. Cell projection > microvillus membrane. Cell projection > ruffle membrane. Cytoplasm > cell cortex. Cytoplasm > cytoskeleton. Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein.

Tissue Specificity:
Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.

Post-translational modifications:
Phosphorylated by tyrosine-protein kinases.

Similarity:
Contains 1 FERM domain.

Database links:
UniProtKB/Swiss-Prot: P15311.4

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

目前研究发现Ezrin蛋白与维持细胞的形状、极性、生长运动以及信号转导方面发挥重要作用,该蛋白与肿瘤的侵袭、转移有关

 

该基因编码的胞质外膜蛋白在微绒毛中起蛋白酪氨酸激酶底物的作用。作为ERM蛋白家族的成员,该蛋白作为质膜和肌动蛋白细胞骨架之间的中间体。该蛋白在细胞表面结构的黏附、迁移和组织中起着关键性的作用,并与多种人类癌症有关。3号染色体上的假基因已被鉴定为该基因。另一种剪接变异体也被描述为该基因。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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