FITC标记的弹性蛋白结合蛋白Fcn2抗体上海沪震实业有限公司

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产品名称: FITC标记的弹性蛋白结合蛋白Fcn2抗体
英文名称: Anti-Ficolin 2/FITC
抗体货号: HZ-13162R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 10:58:00
详细资料:  实验方法技术资料
浏览人数:8
诚信指数:934点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Ficolin 2/FITC Conjugated antibody 

FITC标记的弹性蛋白结合蛋白Fcn2抗体

 

英文名称 Anti-Ficolin 2/FITC
中文名称 FITC标记的弹性蛋白结合蛋白Fcn2抗体
别    名 37 kDa elastin-binding protein; Collagen/fibrinogen domain containing protein 2; Collagen/fibrinogen domain-containing protein 2; EBP 37; EBP-37; EBP37; FCN 2; Fcn2; FCN2_HUMAN; FCNL; Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); Ficolin B; Ficolin beta; Ficolin-2; Ficolin-B; Ficolin-beta; Ficolin2; Hucolin; L ficolin; L-ficolin; OTTHUMP00000022518; P35; RP11 263F14.2; Serum lectin p35.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  免疫学  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ficolin 2/Ficolin B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
产品介绍 background:
Ficolin B is the designation in mouse and rat of a protein also known as L-ficolin, ficolin-2, collagen/fibrinogen domain-containing protein 2, serum lectin p35, EBP-37 or hucolin. Ficolin B is a 313 amino acid member of the ficolin lectin family. It is a secreted innate immunity pattern recognition molecule expressed in liver and plasma that forms a disulfide-linked homopolymer. This extensive N-terminal disulfide bridge formation can lead to a functional dodecamer polypeptide. Ficolin B binds to DNA ligands expressed by late apoptotic and necrotic cells to increase attachment and engulfment. Variation in ficolin B concentrations amongst individuals is associated with polymorphisms in the promoter and structural portion of the FCN2 gene. In patients with Beh鏴t's disease (BD), there exists a significant difference in allele frequency for FCN2 gene single nucleotide polymorphisms (SNPs) within the -557 and -64 promoter sites within HLA-B51 positive and HLA-B51 negative subgroups.

Function:
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.

Subunit:
Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2. 

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed by the liver and secreted in plasma.

Similarity:
Belongs to the ficolin lectin family.
Contains 1 collagen-like domain.
Contains 1 fibrinogen C-terminal domain.

Database links:

Entrez Gene: 2220 Human

Omim: 601624 Human

SwissProt: Q15485 Human

Unigene: 54517 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

Ficolin B在小鼠和大鼠中是一种蛋白质,也称为L-ficolin、ficolin-2、胶原/纤维蛋白原结构域蛋白2、血清凝集素p35、EBP-37或hucolin。Ficolin B是FICOLIN凝集素家族的313氨基酸成员。它是一种分泌的天然免疫模式识别分子,在肝脏和血浆中表达,形成二硫键连接的均聚物。这种广泛的N-末端二硫键形成可导致功能十二聚体多肽。Ficolin B结合晚期凋亡和坏死细胞表达的DNA配体,以增加附着和吞噬。个体间无花果素B浓度的变化与FCN2基因启动子和结构部分的多态性有关。在Beht's disease(BD)患者中,HLA-B51阳性和HLA-B51阴性亚群中,-557和-64启动子区FCN2基因单核苷酸多态性(SNP)等位基因频率存在显著差异。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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