FITC标记的纤连蛋白2抗体
产品名称： FITC标记的纤连蛋白2抗体
英文名称： Anti-Fibulin 2/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Fibulin 2/FITC Conjugated antibody
FITC标记的纤连蛋白2抗体
| 英文名称 | Anti-Fibulin 2/FITC |
| 中文名称 | FITC标记的纤连蛋白2抗体 |
| 别 名 | Fibulin-2; Fbln2; FBLN2_HUMAN; FIBL-2; Fibulin-2; OTTHUMP00000216670; OTTHUMP00000216671; OTTHUMP00000216672. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 124kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Fibulin 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Fibulin-1 and Fibulin-2 associate with Fibronectin and other extracellular matrix proteins. In bone marrow, Fibulin-1 and Fibulin-2 bind to Fibronectin in the adherent layer. Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and as an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. The mobility of cancer cells may be inhibited with increasing exposure to Fibulin-1. Fibulin-2 binds to the lectin domains of extracellular matrix proteins aggrecan, versican and brevican. Fibulin-2 is abundantly expressed in heart, placenta and ovarian tissue, where it localizes to basement membranes and connective tissue compartments. In mice, differential Fibulin-2 gene expression correlates with the early phase of diabetic kidneys and glomerulosclerosis. The gene encoding human Fibulin-2 maps to chromosome 3p25.1. Function: Its binding to fibronectin and some other ligands is calcium dependent. Subunit: Homotrimer; disulfide-linked. Interacts with LAMA2 (By similarity). Subcellular Location: Secreted; extracellular space; extracellular matrix. Tissue Specificity: Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary. Post-translational modifications: O-glycosylated with core 1 or possibly core 8 glycans. It is unsure if the O-glycosylation is on Thr-347 or Ser-348. Similarity: Belongs to the fibulin family. Contains 3 anaphylatoxin-like domains. Contains 11 EGF-like domains. Database links: UniProtKB/Swiss-Prot: P98095.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
腓肠神经纤维蛋白1和腓肠肌蛋白2与纤维连接蛋白及其他细胞外基质蛋白结合。在骨髓中，腓骨蛋白-1和腓肠肌蛋白2与粘附层中的纤维连接蛋白结合。纤维蛋白-1在卵巢癌细胞系中的表达受雌的刺激，已被建议既是卵巢癌细胞转移的代理，又是预测卵巢癌风险或侵袭性的指标。癌细胞的迁移率可随着暴露于腓肠肌-1的增加而被抑制。FiBLIN 2结合细胞外基质蛋白聚集蛋白聚糖、Vistin和BrimiCa的凝集素结构域。纤维蛋白-2在心脏、胎盘和卵巢组织中大量表达，定位于基底膜和结缔组织室。在小鼠中，差异FiBIL-2基因表达与糖尿病肾病和肾小球硬化的早期相关联。编码人腓肠神经素-2的基因定位于染色体3p25.1。