FITC标记的肢体畸形相关蛋白FHOD1抗体-抗体-抗体-生物在线
FITC标记的肢体畸形相关蛋白FHOD1抗体

FITC标记的肢体畸形相关蛋白FHOD1抗体

商家询价

产品名称: FITC标记的肢体畸形相关蛋白FHOD1抗体

英文名称: Anti-FHOD1/FITC

产品编号: HZ-13158R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: ICC=1:50-200 IF=1:50-200

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749
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  • 邮箱 : www.shzbio.net

 Rabbit Anti-FHOD1/FITC Conjugated antibody 

FITC标记的肢体畸形相关蛋白FHOD1抗体

 

英文名称 Anti-FHOD1/FITC
中文名称 FITC标记的肢体畸形相关蛋白FHOD1抗体
别    名 FH1/FH2 domain containing protein; FH1/FH2 domain-containing protein 1; Fhod1; FHOD1_HUMAN; FHOS; FHOS1; Formin homolog overexpressed in spleen 1; Formin homology 2 domain containing 1; Formin homology 2 domain containing protein 1; Formin homology 2 domain-containing protein 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  发育生物学  信号转导  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 126kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FHOD1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The limb deformity (ld) locus influences normal limb development and gives rise to alternative mRNAs that can translate into a family of protein products known as formins. Formins play a crucial role in cytoskeletal reorganization by influencing actin filament assembly. The temporal genetic hierarchy influencing normal limb development can deregulate and mediate mammalian developmental syndromes. FHOD1 induces the formation of and associates with bundled actin stress fibers in response to the activity of the Rho-ROCK cascade. It influences several cellular activities including cell migration, cytoskeletal arrangement, signal transduction and gene expression.

Function:
Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation.

Subunit:
Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus. Interacts with ROCK1 in a Src-dependent manner. 

Subcellular Location:
Cytoplasm. Cytoplasm; cytoskeleton. Predominantly cytoplasmic.

Tissue Specificity:
Ubiquitous. Highly expressed in spleen.

Post-translational modifications:
Phosphorylated by ROCK1. 

Similarity:
Belongs to the formin homology family.
Contains 1 FH1 (formin homology 1) domain.
Contains 1 FH2 (formin homology 2) domain.
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.

Database links:
UniProtKB/Swiss-Prot: Q9Y613.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
   

肢体畸形(ld)基因座影响正常肢体发育,并产生可翻译成蛋白产物家族的替代mRNA,称为formins。通过影响肌动蛋白丝组装,形成素在细胞骨架重组中起着至关重要的作用。影响正常肢体发育的时间遗传层次可以解除和调解哺乳动物发育综合征。FHOD1诱导肌动蛋白应力纤维的形成并与之结合,以响应Rho-Rock级联的活性。它影响多种细胞活动,包括细胞迁移、细胞骨架排列、信号转导和基因表达。