FITC标记的监理蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的监理蛋白抗体
英文名称: Anti-Supervillin/FITC
抗体货号: HZ-7123R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 11:08:00
详细资料:  实验方法技术资料
浏览人数:12
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-Supervillin/FITC Conjugated antibody

FITC标记的监理蛋白抗体

 

英文名称 Anti-Supervillin/FITC
中文名称 FITC标记的监理蛋白抗体
别    名 Archvillin; p205/p250; SVIL_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 248kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Supervillin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Supervillin is an F-actin-binding protein originally with two reported isoforms of 205/250 kDa. The longer isoform, named archvillin, is muscle-specific. Supervillin is a tightly bound peripheral membrane protein that is concentrated at sites of epithelial cell-cell adhesion. It contributes to cell-cell adhesion, motility regulation, and information transfer between cell compartments. The COOH-terminus of supervillin is homologous to villin/gelsolin but is not responsible for the tight binding to the actin cytoskeleton in vivo. The NH2-terminus contains functional nuclear localization sequences and F-actin and myosin II binding domains. It has been suggested that supervillin may mediate actin and myosin II filament organization at cholesterol-rich membrane domains. Supervillin has been identified as a transcriptional activator of the androgen receptor. Supervillin is found in many cells of several species, but is most abundant in muscle, bone marrow, thyroid gland, and salivary gland.

Function:
Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adehesions involves binding to TRIP6 (By similarity). 

Subunit:
Associates with F-actin. Interacts with NEB. Interacts with MYH9. Interacts with MYLK. Isoform 2 interacts with TRIP6. Isoform 2 interacts with DYNLT1 (By similarity). 

Subcellular Location:
Cell membrane; peripheral membrane protein; cytoplasmic side. Cytoplasm; cytoskeleton.

Tissue Specificity:
Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific. 

Similarity:
Belongs to the villin/gelsolin family. 
Contains 5 gelsolin-like repeats. 
Contains 1 HP (headpiece) domain.

Database links:

Entrez Gene: 6840 Human

Omim: 604126 Human

SwissProt: O95425 Human

SwissProt: Q569J5 Human

Unigene: 499209 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

超级绒毛蛋白是一种F-肌动蛋白结合蛋白,最初有两种报告的205/250 kDa的异构体。较长的异构体,命名为Cavigin,是肌肉特异性的。超绒毛膜是紧密结合的外周膜蛋白,集中在上皮细胞-细胞粘附部位。它有助于细胞间粘附、运动调节和细胞室间的信息传递。超绒毛蛋白的COOH末端与绒毛蛋白/凝胶溶胶同源,但不负责与肌动蛋白细胞骨架在体内的紧密结合。NH2末端含有功能性核定位序列和F-肌动蛋白和肌球蛋白II结合结构域。它已经表明,监理蛋白可能介导肌动蛋白和肌球蛋白丝富含胆固醇的膜结构域组织。超绒毛素已被鉴定为雄***受体的转录激活因子。监理蛋白在几个物种的细胞中发现的,但是是最丰富的肌肉、骨髓、甲状腺、唾液腺。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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