FITC标记的原癌基因c FGR抗体上海沪震实业有限公司

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产品名称: FITC标记的原癌基因c FGR抗体
英文名称: Anti-FGR/FITC
抗体货号: HZ-13157R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 11:09:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-FGR/FITC Conjugated antibody

FITC标记的原癌基因c FGR抗体

 

英文名称 Anti-FGR/FITC
中文名称 FITC标记的原癌基因c FGR抗体
别    名 c fgr; c fgr protooncogene; c src 2 proto oncogene; c src2; FGR; FLJ43153; Gardner Rasheed feline sarcoma viral (v fgr); Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog; MGC75096; p55 c fgr protein; P55 FGR; p55c fgr; p58c fgr; Proto oncogene c Fgr; Proto oncogene tyrosine protein kinase FGR; SRC 2; SRC2; Tyrosine protein kinase Fgr; FGR_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FGR/SRC2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
产品介绍 background:
Src is the human homolog of the v-Src gene of the rous sarcoma virus, also designated avian sarcoma virus or ASV. Src was the first proto-oncogenic non-receptor tyrosine kinase characterized in human. The Src family, which has common structural motifs, is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility and adhesion. Src-family ki-nases contain an amino-terminal cell membrane anchor followed by an SH3 domain and an SH2 domain, which are involved in modular association and activation, respectively. Src-family kinases, which are normally maintained in an inactive state and can be activated transiently during cellular events such as mitosis. Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization and membrane trafficking. c-Fgr is a human non-receptor tyrosine kinase family member that was discovered by using a probe toward the v-Fgr portion of the cell-derived domain of Gardner-Rasheed feline sarcoma virus. The human c-Fgr gene encodes a 529 amino acid protein.

Function:
Fgr is a member of the Src family of non-receptor tyrosine kinases. It is expressed in neutrophils, monocytes, macrophages and natural killer cells. Expression of Fgr is developmentally regulated and required in normal myelomonocytic differentiation in vivo. HL-60 cells induced to differentiate with retinoic acid express high levels of Fgr.

Subunit:
Interacts with ITGB1, ITGB2, MS4A2/FCER1B, FCER1G, FCGR2A and/or FCGR2B. Interacts (via SH2 domain) with SYK (tyrosine phosphorylated). Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with PTK2/FAK1. Interacts (via SH2 domain) with HCLS1 (tyrosine phosphorylated by SYK). Interacts with SIRPA and PTPNS1. Interacts (not phosphorylated on tyrosine residues) with CBL; FGR tyrosine phosphorylation promotes dissociation. Interacts with PIK3R1 and FASLG (By similarity). 

Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side Probable. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection ?ruffle membrane. Cytoplasm ?cytosol. Cytoplasm ?cytoskeleton. Mitochondrion inner membrane. Mitochondrion intermembrane space. Note: Detected in mitochondrial intermembrane space and at inner membranes. Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. 

Tissue Specificity:
Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.

Post-translational modifications:
Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation. 
Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412. 

DISEASE:
Note=Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cell proliferation. 

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. 
Contains 1 protein kinase domain. 
Contains 1 SH2 domain. 
Contains 1 SH3 domain. 

Database links:

Entrez Gene: 2268 Human

Entrez Gene: 14191 Mouse

NCBI: 4885235 Human

Omim: 164940 Human

SwissProt: P09769 Human

SwissProt: P14234 Mouse

Unigene: 1422 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

Src是RUS肉瘤病毒的V-Src基因的人类同源物,也被命名为禽肉瘤病毒或ASV。Src是人类首次发现的原癌基因非受体酪氨酸激酶。Src家族由脊椎动物中的九个成员组成,包括Src、Yes、Fgr、Frk、Fyn、Lyn、Hck、Lck和Blk。Src-家族激酶可以传递参与多种细胞过程控制的信号,包括细胞增殖、分化、运动和粘附。Src-家族激酶包含一个氨基末端细胞膜锚,接着是一个SH3结构域和一个SH2结构域,它们分别参与模块结合和激活。Src家族激酶,通常维持在非活性状态,在细胞事件(如有丝分裂)期间可短暂激活。Src家族激酶的不同亚细胞定位可能对特定的细胞过程如有丝分裂、细胞骨架组织和膜运输的调控很重要。c-Fgr是利用对Gardner-Rasheed猫肉瘤病毒细胞衍生结构域的v-Fgr部分的探针发现的人类非受体酪氨酸激酶家族成员。人cFGR基因编码529个氨基酸蛋白。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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