FITC标记的磷酸化丝切蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的磷酸化丝切蛋白抗体
英文名称: Anti-phospho-Cofilin (Ser24)/FITC
抗体货号: HZ-10252R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 11:10:00
详细资料:  实验方法技术资料
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诚信指数:932点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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上海·中国-上海
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产品详细描述

 Rabbit Anti-phospho-Cofilin (Ser24)/FITC Conjugated antibody

FITC标记的***酸化丝切蛋白抗体

 

英文名称 Anti-phospho-Cofilin (Ser24)/FITC
中文名称 FITC标记的***酸化丝切蛋白抗体
别    名 Cofilin/CFL1 (Ser24); 18 kDa phosphoprotein; CFL 1; CFL; CFL1; Cofilin 1; Cofilin 1 non muscle; Cofilin non muscle isoform; p18; COF1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  信号转导  细胞凋亡  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Guinea Pig, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human CFL1/CFL2 around the phosphorylation site of Ser24
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.

Function:
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Subunit:
Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods.

Subcellular Location:
Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.

Tissue Specificity:
Widely distributed in various tissues.

Post-translational modifications:
Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.

Similarity:
Belongs to the actin-binding proteins ADF family.
Contains 1 ADF-H domain.

Database links:

Entrez Gene: 1072 Human

Entrez Gene: 12631 Mouse

Entrez Gene: 29271 Rat

Omim: 601442 Human

SwissProt: P23528 Human

SwissProt: P18760 Mouse

SwissProt: P45592 Rat

Unigene: 170622 Human

Unigene: 329655 Mouse

Unigene: 11675 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

由该基因编码的蛋白可以以pH依赖的方式聚合和解聚F-肌动蛋白和G-肌动蛋白。LIM激酶的这种***酸化增加了Rho诱导的肌动蛋白细胞骨架的重组。辅丝蛋白是一种广泛分布的细胞内肌动蛋白调节蛋白,它结合和解聚丝状的F-肌动蛋白,并以pH依赖的方式抑制单体G-肌动蛋白的聚合。它参与肌动蛋白-丝素蛋白复合物从细胞质向细胞核的转运。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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