FITC标记的FHOD3蛋白抗体
产品名称： FITC标记的FHOD3蛋白抗体
英文名称： Anti-FHOD3/FITC
产品编号： HZ-13156R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-FHOD3/FITC Conjugated antibody
FITC标记的FHOD3蛋白抗体
| 英文名称 | Anti-FHOD3/FITC |
| 中文名称 | FITC标记的FHOD3蛋白抗体 |
| 别 名 | FLJ22717; Formactin2; FH1/FH2 domain containing protein 3; FH1/FH2 domain-containing protein 3; Fhod3; FHOD3_HUMAN; FHOS2; FLJ22297; FLJ22717; Formactin-2; Formactin2; Formin homolog overexpressed in spleen 2; Formin homology 2 domain containing 3; hFHOS2; KIAA1695; mKIAA1695. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞骨架 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 159kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Supervillin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FHOD3 (formin homology 2 domain containing 3), also known as FHOS2 or KIAA1695, is a 1,422 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one DAD domain, one FH1 domain, one FH2 domain and one GBD/FH3 domain. Expressed in brain, heart and kidney, FHOD3 interacts with intermediate filaments and functions as an Actin-organizing protein that is thought to promote the formation of stress fibers in conjunction with cellular elongation. Multiple isoforms of FHOD3 exist due to alternative splicing events. The gene encoding FHOD3 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas. Function: Actin-organizing protein that may cause stress fiber formation together with cell elongation. Subunit: Interacts with nestin/NES-based interfilament (IF) (By similarity). Interacts with SQSTM1; isoform 4 threonine phosphorylation disrupts SQSTM1-binding. Subcellular Location: Cytoplasm; cytoskeleton. Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining. Tissue Specificity: Expressed in the heart, kidney and brain. Similarity: Belongs to the formin homology family. Contains 1 DAD (diaphanous autoregulatory) domain. Contains 1 FH1 (formin homology 1) domain. Contains 1 FH2 (formin homology 2) domain. Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. Database links: Entrez Gene: 80206 Human Entrez Gene: 225288 Mouse Entrez Gene: 291731 Rat Omim: 609691 Human SwissProt: Q2V2M9 Human SwissProt: Q76LL6 Mouse Unigene: 630884 Human Unigene: 329322 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FHOD3（甲酸同系物2结构域包含3），也称为FHOS2或KIAA1695，是一种1422个氨基酸蛋白，定位于细胞质和细胞骨架，并包含一个DAD结构域、一个FH1结构域、一个FH2结构域和一个GbD/FH3结构域。在大脑、心脏和肾脏中表达，FHOD3与中间丝相互作用，并起到肌动蛋白组织蛋白的作用，被认为促进结合细胞伸长的应力纤维的形成。FHD3的多个异构体由于选择性剪接事件而存在。编码FHOD3的基因定位于人类18号染色体，其含有超过300个蛋白质编码基因并含有近7600万个碱基。在染色体18定位基因中存在多种疾病，其中一些包括三体性18（也称为爱德华兹综合征）、尼曼-匹克病、遗传性出血性毛细血管扩张症、红细胞生成性原卟啉症和滤泡性淋巴瘤。