FITC标记的FCHO1蛋白抗体
产品名称： FITC标记的FCHO1蛋白抗体
英文名称： Anti-FCHO1/FITC
产品编号： HZ-13152R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FCHO1/FITC Conjugated antibody
FITC标记的FCHO1蛋白抗体
| 英文名称 | Anti-FCHO1/FITC |
| 中文名称 | FITC标记的FCHO1蛋白抗体 |
| 别 名 | FCH domain only 1; FCH domain only protein 1; FCHO 1; KIAA0290; FCHO1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转运蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 97kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FCHO1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FCHO1 (FCH domain only 1) is an 889 amino acid protein that contains one FCH domain and exists as multiple alternatively spliced isoforms. The gene encoding FCHO1 maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc receptors (FcRs). Key genes for eye color and hair color also map to chromosome 19. Function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors (By similarity). Subunit: May oligomerize and form homotetramer (By similarity). Interacts with AP2A2 and AP2B1; 2 subunits of the adaptor protein complex AP-2. Interacts with DAB2. Interacts with clathrin (CLTC or CLTCL1). Interacts with EPS15, EPS15R and ITSN1. Interacts with AGFG1 and CALM. May interact with ACVR1; linking this receptor to clathrin-mediated endocytosis. Subcellular Location: Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side (Probable). Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes. Similarity: FCHO1 is involved in clathrin-coated vesicle formation. Database links: UniProtKB/Swiss-Prot: O14526.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FCHO1（FCH结构域仅1）是一个889氨基酸的蛋白质，包含一个FCH结构域，并以多种选择性剪接异构体存在。编码FCHO1的基因定位于人类19号染色体，该染色体由超过6300万个碱基组成，包含大约1400个基因，并且被认为是人类染色体上具有最大基因密度的基因。它是许多免疫球蛋白（Ig）超家族成员的遗传宿主，包括杀伤细胞和白细胞Ig样受体、多个ICAMs、CEACAM和PSG家族和Fc受体（FCRS）。眼睛颜色和头发颜色的关键基因也映射到19号染色体上。