FITC标记的神经生长因子受体抗体上海沪震实业有限公司

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产品名称: FITC标记的神经生长因子受体抗体
英文名称: Anti-p75 NGF Receptor/FITC
抗体货号: HZ-7122R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/14 11:23:00
详细资料:  实验方法技术资料
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诚信指数:962点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-p75 NGF Receptor/FITC Conjugated antibody

FITC标记的神经生长因子受体抗体

 

英文名称 Anti-p75 NGF Receptor/FITC
中文名称 FITC标记的神经生长因子受体抗体
别    名 NGFR; Gp80 LNGFR; ngfrp75; Low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; NGF receptor; p75 ICD; CD271; CD271 antigen; Gp80 LNGFR; Low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Nerve growth factor receptor; Nerve growth factor receptor TNFR superfamily member 16; NGF receptor; NGFR; p75 ICD; p75 Neurotrophin receptor; p75 NTR; TNFR Superfamily Member 16; TNFRSF16; Tumor necrosis factor receptor superfamily member 16; TNR16_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, 
产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NGFR/p75NTR
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells. NGF is important for the development, differentiation and survival of a variety of neuronal and non-neuronal cells. Its action is mediated by binding to two distinct receptors, the high affinity p140 and low affinity p75. p75NGFR binds neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, and NT-6. p75NGFR belongs to the TNF-R superfamily and is reported to mediate NGF-induced apoptosis.

Function:
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.

Subunit:
Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1 (By similarity). Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with NRADD.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Post-translational modifications:
N- and O-glycosylated. Phosphorylated on serine residues.

Similarity:
Contains 1 death domain. Contains 4 TNFR-Cys repeats. 

Database links:

Entrez Gene: 4804 Human

Entrez Gene: 18053 Mouse

Entrez Gene: 24596 Rat

Omim: 162010 Human

SwissProt: P08138 Human

SwissProt: Q9Z0W1 Mouse

SwissProt: P07174 Rat

Unigene: 415768 Human

Unigene: 681726 Human

Unigene: 283893 Mouse

Unigene: 10980 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

低亲和力NGFR(神经生长因子受体)是一种跨越75kDa膜的糖蛋白,缺乏内在的酪氨酸激酶活性。p75 NGFR与TrkA,高亲和力NGF受体相互作用,并在低NGF浓度下增强TrkA信号。p75受体结合神经生长因子、脑源性神经营养因子、神经营养素-3和神经营养素-4具有不同的特异性。p75NGFR在神经营养因子信号转导中起着重要作用,并已被证明调节选择性细胞群对程序性细胞死亡的易感性。它表达于多种神经细胞类型,包括多种胚胎形式,该受体可用于分离神经祖细胞。NGF对多种神经元和非神经细胞的发育、分化和存活具有重要意义。其作用是通过结合两个不同的受体,高亲和力P140和低亲和力P75介导的。p75 NGFR结合神经营养因子,包括脑源性神经营养因子(BDNF)、神经营养因子-3(NT-3)、NT-4/5和NT-6。p75 NGFR属于TNF- R超家族,据报道介导NGF诱导的细胞凋亡。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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