Rabbit Anti-p75 NGF Receptor/FITC Conjugated antibody
|英文名称||Anti-p75 NGF Receptor/FITC|
|别 名||NGFR; Gp80 LNGFR; ngfrp75; Low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; NGF receptor; p75 ICD; CD271; CD271 antigen; Gp80 LNGFR; Low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Nerve growth factor receptor; Nerve growth factor receptor TNFR superfamily member 16; NGF receptor; NGFR; p75 ICD; p75 Neurotrophin receptor; p75 NTR; TNFR Superfamily Member 16; TNFRSF16; Tumor necrosis factor receptor superfamily member 16; TNR16_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 神经生物学 信号转导|
|交叉反应||Human, Mouse, Rat, Dog,|
|产品应用||Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||42kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human NGFR/p75NTR|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells. NGF is important for the development, differentiation and survival of a variety of neuronal and non-neuronal cells. Its action is mediated by binding to two distinct receptors, the high affinity p140 and low affinity p75. p75NGFR binds neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, and NT-6. p75NGFR belongs to the TNF-R superfamily and is reported to mediate NGF-induced apoptosis.
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1 (By similarity). Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with NRADD.
Membrane; Single-pass type I membrane protein.
N- and O-glycosylated. Phosphorylated on serine residues.
Contains 1 death domain. Contains 4 TNFR-Cys repeats.
Entrez Gene: 4804 Human
Entrez Gene: 18053 Mouse
Entrez Gene: 24596 Rat
Omim: 162010 Human
SwissProt: P08138 Human
SwissProt: Q9Z0W1 Mouse
SwissProt: P07174 Rat
Unigene: 415768 Human
Unigene: 681726 Human
Unigene: 283893 Mouse
Unigene: 10980 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
低亲和力NGFR（神经生长因子受体）是一种跨越75kDa膜的糖蛋白，缺乏内在的酪氨酸激酶活性。p75 NGFR与TrkA，高亲和力NGF受体相互作用，并在低NGF浓度下增强TrkA信号。p75受体结合神经生长因子、脑源性神经营养因子、神经营养素-3和神经营养素-4具有不同的特异性。p75NGFR在神经营养因子信号转导中起着重要作用，并已被证明调节选择性细胞群对程序性细胞死亡的易感性。它表达于多种神经细胞类型，包括多种胚胎形式，该受体可用于分离神经祖细胞。NGF对多种神经元和非神经细胞的发育、分化和存活具有重要意义。其作用是通过结合两个不同的受体，高亲和力P140和低亲和力P75介导的。p75 NGFR结合神经营养因子，包括脑源性神经营养因子（BDNF）、神经营养因子-3（NT-3）、NT-4／5和NT-6。p75 NGFR属于TNF- R超家族，据报道介导NGF诱导的细胞凋亡。