Rabbit Anti-FARP1/FITC Conjugated antibody
|别 名||CDEP; Chondrocyte derived ezrin like protein; FERM RhoGEF and pleckstrin domain containing protein 1; FERM RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived). PLEKHC2; FARP1_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 神经生物学 细胞类型标志物 细胞骨架|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||119kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human FARP1|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
FARP1 (FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1), also known as PLEKHC2 or CDEP, is a 1,045 amino acid protein that contains one FERM domain, one DH domain and two PH domains. Existing as multiple alternatively spliced isoforms that are expressed in fetal heart, brain and spleen, as well as in adult lung, kidney and testis, FARP1 is thought to function as a Rho-guanine nucleotide exchange factor that may play a role in linking the cell membrane to the cytoskeleton. The gene encoding FARP1 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.
The FARP1 protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain, and is believed to be a member of the band 4.1 superfamily, whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for the FARP1 gene, which shows increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes.
Contains 1 DH (DBL-homology) domain.
Contains 1 FERM domain.
Contains 2 PH domains.
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
farp1（FERM（SA-RHOGEF和pleckstrin，arhgef）域蛋白1），所以称为plekhc2或cdep，is a 1045氨基酸蛋白FERM域包含一个域，一个域的DH和pH值。现有的AS spliced isoforms也多是以胎儿心脏、脑和脾，工作人员在***肺，肾和睾丸的功能，farp1是思想作为一个鸟嘌呤核苷酸交换因子的Rho -这可能发挥的作用细胞膜形成一个cytoskeleton。基因编码的人力farp1地图染色体13，这房子过400个基因，如BRCA2和Rb1，和包括近4 %的人类基因组。三体13三体综合征，也被称为王牌，谁是致命的和过去几年遭受一个永久生存的困难和漏洞neurologic缺损，严重呼吸道感染到食。