Rabbit Anti-DENN/FITC Conjugated antibody
|别 名||Differentially expressed in normal and neoplastic cells; FLJ35600; IG20; ***oma glucagonoma clone 20; KIAA0358; MADD; MADD_HUMAN; MAP kinase-activating death domain protein; Rab3 GDP/GTP exchange factor; RAB3GEP.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 细胞凋亡|
|交叉反应||Human, Mouse, Rat, Dog, Cow, Horse, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||183kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human DENN|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines.
Belongs to the MADD family.
Contains 1 dDENN domain.
Contains 1 death domain.
Contains 1 DENN domain.
Contains 1 uDENN domain.
Entrez Gene: 8567 Human
Entrez Gene: 228355 Mouse
Entrez Gene: 94193 Rat
Omim: 603584 Human
SwissProt: Q8WXG6 Human
SwissProt: Q80U28 Mouse
SwissProt: O08873 Rat
Unigene: 82548 Human
Unigene: 36410 Mouse
Unigene: 90117 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
肿瘤坏死因子α（TNF-α）是一种信号分子，与细胞凋亡靶向细胞上的两种受体之一相互作用。凋亡信号通过胞质转运体蛋白转导于这些细胞内。该基因编码的蛋白是含有死亡结构域的适配子蛋白，它与TNF-α受体1的死亡结构域相互作用，激活有丝分裂原激活蛋白激酶（MAPK）并传播凋亡信号。它在肿瘤细胞中的膜结合和表达水平高于正常细胞。已经描述了几种编码不同亚型的转录本变体。[ RefSeq，JUL 2008 ]