FITC标记的死亡结构域接头蛋白DENN抗体上海沪震实业有限公司

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产品名称: FITC标记的死亡结构域接头蛋白DENN抗体
英文名称: Anti-DENN/FITC
抗体货号: HZ-14268R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/10/11 10:59:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-DENN/FITC Conjugated antibody

FITC标记的死亡结构域接头蛋白DENN抗体

 

英文名称 Anti-DENN/FITC
中文名称 FITC标记的死亡结构域接头蛋白DENN抗体
别    名 Differentially expressed in normal and neoplastic cells; FLJ35600; IG20; ***oma glucagonoma clone 20; KIAA0358; MADD; MADD_HUMAN; MAP kinase-activating death domain protein; Rab3 GDP/GTP exchange factor; RAB3GEP.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 183kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DENN
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Function:
Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.

Subcellular Location:
Membrane.

Tissue Specificity:
Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines.

Similarity:
Belongs to the MADD family.
Contains 1 dDENN domain.
Contains 1 death domain.
Contains 1 DENN domain.
Contains 1 uDENN domain.

Database links:

Entrez Gene: 8567 Human

Entrez Gene: 228355 Mouse

Entrez Gene: 94193 Rat

Omim: 603584 Human

SwissProt: Q8WXG6 Human

SwissProt: Q80U28 Mouse

SwissProt: O08873 Rat

Unigene: 82548 Human

Unigene: 36410 Mouse

Unigene: 90117 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

肿瘤坏死因子α(TNF-α)是一种信号分子,与细胞凋亡靶向细胞上的两种受体之一相互作用。凋亡信号通过胞质转运体蛋白转导于这些细胞内。该基因编码的蛋白是含有死亡结构域的适配子蛋白,它与TNF-α受体1的死亡结构域相互作用,激活有丝分裂原激活蛋白激酶(MAPK)并传播凋亡信号。它在肿瘤细胞中的膜结合和表达水平高于正常细胞。已经描述了几种编码不同亚型的转录本变体。[ RefSeq,JUL 2008 ]

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