FITC标记的DENND1C蛋白抗体
产品名称： FITC标记的DENND1C蛋白抗体
英文名称： Anti-DENND1C/FITC
产品编号： HZ-14270R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-DENND1C/FITC Conjugated antibody
FITC标记的DENND1C蛋白抗体
| 英文名称 | Anti-DENND1C/FITC |
| 中文名称 | FITC标记的DENND1C蛋白抗体 |
| 别 名 | Connecdenn 3; DEN1C_HUMAN; DENN domain-containing protein 1C; Dennd1c; FAM31C; FLJ22757; Protein FAM31C. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞骨架 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 87kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DENND1C |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010] Function: Guanine nucleotide exchange factor (GEF) for RAB35 Subunit: Exhibits low nucleotide-independent RAB35-binding activity. Interacts with clathrin heavy chain/CLTC and with AP2A2, but not with AP2B1. Subcellular Location: Cytoplasm; cytosol. Cytoplasmic vesicle; clathrin-coated vesicle. Similarity: Contains 1 dDENN domain. Contains 1 DENN domain. Contains 1 uDENN domain Database links: Entrez Gene: 79958 Human Omim: 613634 Human SwissProt: Q8IV53 Human Unigene: 236449 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Clathrin（见MIM 118955）介导的内吞作用是蛋白质和脂质内化的主要机制。Connecdenn家族的成员，如DENND1C，在早期内体小GTPase RAB35（MIM 604199）中起鸟嘌呤核苷酸交换因子（GEF）的作用，并与包涵体和包涵体适配子蛋白-2（AP2；参见MIM 601024）结合。因此，connecdenns将RAB35的激活与包涵体机械联系起来（Marat和McPherson，2010[PubMed 20154091]）。