FITC标记的DENND3蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的DENND3蛋白抗体
英文名称: Anti-DENND3/FITC
抗体货号: HZ-14271R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/10/11 11:02:00
详细资料:  实验方法技术资料
浏览人数:9
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-DENND3/FITC Conjugated antibody

FITC标记的DENND3蛋白抗体

 

英文名称Anti-DENND3/FITC中文名称FITC标记的DENND3蛋白抗体别    名DEND3_HUMAN; DENN domain-containing protein 3; DENN/MADD domain containing 3; Dennd3; KIAA0870.  规格价格100ul/2980元 购买        大包装/询价说 明 书100ul  研究领域细胞生物  信号转导  G蛋白信号  抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, 产品应用ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.分 子 量136kDa性    状Lyophilized or Liquid浓    度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human DENND3亚    型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background:
DENND3 is a 1,198 amino acid protein that contains a single DENN, dDENN and uDENN domain, as well as three WD repeats. Existing as four alternatively spliced isoforms, the DENND3 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 8q24.3. Made up of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome.

Function:
Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferring receptor.

Similarity:
Contains 1 dDENN domain.
Contains 1 DENN domain.
Contains 1 uDENN domain.
Contains 3 WD repeats.

Database links:

Entrez Gene: 22898 Human

SwissProt: A2RUS2 Human

Unigene: 18166 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
 
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   

DEND3是一个1198个氨基酸的蛋白质,包含一个DNN,DDEN和UdNn结构域,以及三个WD重复序列。DENND3基因在黑猩猩、狗、奶牛、小鼠、大鼠、鸡和斑马鱼中以四种可选择的剪接异构体存在,并定位于人染色体8q24.3。由近1亿4600万个碱基组成,8号染色体编码约800个基因。在一些白血病和淋巴瘤中发现第8染色体部分易位,并伴有c-Myc基因的扩增,并且通常与较差的预后相关。8号染色体的部分与精神分裂症和双相情感障碍有关。WRN是由8号染色体编码的DNA解旋酶,在早期衰老障碍沃纳综合征中显示出缺陷。第8号染色体也与菲佛综合征、先天性甲状腺功能减退症和Waord-Burg综合征有关。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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