Rabbit Anti-Dermatopontin/FITC Conjugated antibody
|别 名||DERM_HUMAN; Dermatopontin; Dpt; TRAMP; Tyrosine rich acidic matrix protein; Tyrosine-rich acidic matrix protein.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||信号转导 细胞骨架 细胞外基质|
|交叉反应||Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||24kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human Dermatopontin|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008]
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.
Secreted > extracellular space > extracellular matrix.
Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.
Sulfated on tyrosine residue(s).
Belongs to the dermatopontin family.
Entrez Gene: 1805 Human
Omim: 125597 Human
SwissProt: Q07507 Human
Unigene: 80552 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
Dermatopontin是一种细胞外基质蛋白，可能在细胞基质相互作用和基质组装中发挥作用。蛋白质在多种组织中发现，许多酪氨酸残基都是硫酸化的。Dermatopontin被假定为通过与核心蛋白聚糖的相互作用来改变TGF-β的行为。[ RefSeq，JUL 2008 ]