|别 名||Copine 1; Copine I; Copine-1; Copine1; CopineI; COPN 1; COPN1; CPN 1; CPN1; CPNE 1; CPNE1; CPNE1_HUMAN; MGC1142.|
|规格价格||100ul/1380元 购买 200ul/2200元 购买 大包装/询价|
|说 明 书||100ul 200ul|
|研究领域||肿瘤 细胞生物 信号转导 转运蛋白|
|交叉反应||Human, Mouse, Rat, Pig, Cow, Sheep,|
|产品应用||WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||59kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human CPNE1:1-120/537|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Copine I is a member of the copine family of evolutionarily conserved, soluble, calcium-dependent, membrane-binding proteins. Members of the copine family are involved in signal transduction and membrane trafficking. Copine I is ubiquitously expressed and contains two N-terminal C2 domains and one C-terminal VWFA (von Willebrand factor A) domain, which is also referred to as the A domain or the core domain. As is characteristic of the copine family, copine I functions in membrane trafficking and is capable of binding phospholipids in a calcium-dependent manner. Copine I is also able to bind liposomes. Via its VWFA domain, copine I directly interacts with the ubiquitin-conjugating enzyme, UBC12, and may play a role in the regulation of TNF alpha-signaling.
May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties.
Interacts with CCDC22.
Belongs to the copine family.
Contains 2 C2 domains.
Contains 1 VWFA domain.
Entrez Gene: 615677 Cow
Entrez Gene: 477213 Dog
Entrez Gene: 8904 Human
Entrez Gene: 266692 Mouse
Entrez Gene: 100233174 Pig
Entrez Gene: 100328904 Rabbit
Omim: 604205 Human
SwissProt: Q99829 Human
SwissProt: Q8C166 Mouse
Unigene: 246413 Human
Unigene: 700188 Human
Unigene: 27660 Mouse
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.