|别 名||Major synaptic vesicle protein P38; MRXSYP; Syn p38; Synaptophysin; SYP; SYPH; SYPH_HUMAN; SypI.|
|规格价格||100ul/1380元 购买 200ul/2200元 购买 大包装/询价|
|说 明 书||100ul 200ul|
|交叉反应||Human, Mouse, Rat,|
|产品应用||WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||34kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human Synaptophysin :201-300/313 <Cytoplasmic>|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011]
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome.
Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Defects in SYP are the cause of mental retardation X-linked SYP-related (MRXSYP) [MIM:300802]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
Belongs to the synaptophysin/synaptobrevin family. Contains 1 MARVEL domain.
Entrez Gene: 280937 Cow
Entrez Gene: 6855 Human
Entrez Gene: 20977 Mouse
Entrez Gene: 24804 Rat
Omim: 313475 Human
SwissProt: P20488 Cow
SwissProt: P08247 Human
SwissProt: Q62277 Mouse
SwissProt: P07825 Rat
Unigene: 632804 Human
Unigene: 223674 Mouse
Unigene: 11067 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.