FITC标记的DHX36蛋白抗体
产品名称: FITC标记的DHX36蛋白抗体
英文名称: Anti-DHX36/FITC
产品编号: HZ-14319R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DHX36/FITC Conjugated antibody
FITC标记的DHX36蛋白抗体
英文名称 | Anti-DHX36/FITC |
中文名称 | FITC标记的DHX36蛋白抗体 |
别 名 | DDX36; DEAH box protein 36; Dhx36; DHX36_HUMAN; EC 3.6.1.-; KIAA1488; MLE like protein 1; MLE-like protein 1; MLEL1; Probable ATP dependent RNA helicase DHX36; Probable ATP-dependent RNA helicase DHX36; RHAU; RNA helicase associated with AU rich element ARE; RNA helicase associated with AU-rich element ARE. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 免疫学 表观遗传学 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 115kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human DHX36 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Function: Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. Subcellular Location: Nucleus. Cytoplasm. Isoform 1 preferentially localized to the nucleus and isoform 2 localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli. Tissue Specificity: Highly expressed in testis. Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Database links: Entrez Gene: 170506 Human Entrez Gene: 72162 Mouse Omim: 612767 Human SwissProt: Q9H2U1 Human SwissProt: Q8VHK9 Mouse Unigene: 446270 Human Unigene: 224233 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因是RNA依赖性NTPases的DEAH盒家族的成员,该家族以保守的氨基酸序列Asp-Glu-Ala-His命名。该基因编码的蛋白具有增强3’-UTR-AU-丰富元件(ARE-mRNA)mRNA的脱脱甲基和衰变的作用。该蛋白还被证明能将高度稳定的四分子DNA构型(G4)分解为单链,该构型能在富含鸟嘌呤的DNA区域自发形成。选择性剪接导致多个转录子变体编码不同的亚型。[ RefSeq,JUL 2008 ]