FITC标记的富含亮氨酸重复结构域蛋白6抗体上海沪震实业有限公司

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产品名称: FITC标记的富含亮氨酸重复结构域蛋白6抗体
英文名称: Anti-NALP6/FITC
抗体货号: HZ-10440R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/12/8 14:49:00
详细资料:  实验方法技术资料
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诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-NALP6/FITC Conjugated antibody 

FITC标记的富含亮氨酸重复结构域蛋白6抗体

 

英文名称 Anti-MGST1/FITC
中文名称 FITC标记的微粒体谷胱甘肽S转移酶1抗体
别    名 MGST1; Glutathione S transferase 12; Microsomal glutathione transferase 1; GST12; MGST 1; MGST; MGST1; MGST1_HUMAN; Microsomal glutathione S-transferase 1; Microsomal GST 1; Microsomal GST-1; Microsomal GST-I.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  信号转导  Alzheimer's  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应  
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MGST1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

Subcellular Location:
Microsome. Mitochondrion outer membrane. Endoplasmic reticulum membrane.

Tissue Specificity:
Highly expressed in liver.

Post-translational modifications:
Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.

Similarity:
Belongs to the MAPEG family.

Database links:

Entrez Gene: 4257 Human

Entrez Gene: 56615 Mouse

Entrez Gene: 171341 Rat

Omim: 138330 Human

SwissProt: P10620 Human

SwissProt: Q91VS7 Mouse

SwissProt: P08011 Rat

Unigene: 389700 Human

Unigene: 14796 Mouse

Unigene: 2580 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
   

NALPS是细胞质蛋白,在较大的卡特彼勒蛋白家族中形成亚家族。大多数短NALP,如NALP6,具有N-末端pyrin(MEFV;MIM 608107)结构域(PYD),随后是NACHT结构域、NACHT相关结构域(NAD)和C-末端富亮氨酸重复序列(LRR)区域。长NALP,NALP1(MIM 606636),还具有C端扩展,包含查找域(FIIND)和caspase招聘域(CARD)的功能。NALP通过参与被称为炎症小体的多蛋白复合物而参与促炎性caspases(例如,CASP1;MIM 147678)的激活(Tschopp等人,2003[PubMed 12563287])。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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