FITC标记的富含亮氨酸重复结构域蛋白6抗体
产品名称： FITC标记的富含亮氨酸重复结构域蛋白6抗体
英文名称： Anti-NALP6/FITC
产品编号： HZ-10440R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-NALP6/FITC Conjugated antibody
FITC标记的富含亮氨酸重复结构域蛋白6抗体
| 英文名称 | Anti-MGST1/FITC |
| 中文名称 | FITC标记的微粒体谷胱甘肽S转移酶1抗体 |
| 别 名 | MGST1; Glutathione S transferase 12; Microsomal glutathione transferase 1; GST12; MGST 1; MGST; MGST1; MGST1_HUMAN; Microsomal glutathione S-transferase 1; Microsomal GST 1; Microsomal GST-1; Microsomal GST-I. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 Alzheimer's |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MGST1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012] Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity. Subcellular Location: Microsome. Mitochondrion outer membrane. Endoplasmic reticulum membrane. Tissue Specificity: Highly expressed in liver. Post-translational modifications: Peroxynitrite induces nitration at Tyr-93 which activates the enzyme. Similarity: Belongs to the MAPEG family. Database links: Entrez Gene: 4257 Human Entrez Gene: 56615 Mouse Entrez Gene: 171341 Rat Omim: 138330 Human SwissProt: P10620 Human SwissProt: Q91VS7 Mouse SwissProt: P08011 Rat Unigene: 389700 Human Unigene: 14796 Mouse Unigene: 2580 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
NALPS是细胞质蛋白，在较大的卡特彼勒蛋白家族中形成亚家族。大多数短NALP，如NALP6，具有N-末端pyrin(MEFV；MIM 608107)结构域(PYD)，随后是NACHT结构域、NACHT相关结构域(NAD)和C-末端富亮氨酸重复序列(LRR)区域。长NALP，NALP1（MIM 606636），还具有C端扩展，包含查找域（FIIND）和caspase招聘域（CARD）的功能。NALP通过参与被称为炎症小体的多蛋白复合物而参与促炎性caspases(例如，CASP1；MIM 147678)的激活(Tschopp等人，2003[PubMed 12563287])。