FITC标记的白喉毒素B抗体上海沪震实业有限公司

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产品名称: FITC标记的白喉毒素B抗体
英文名称: Anti-Diphtheria toxin fragment B/FITC
抗体货号: HZ-10668R-FITC
产品规格: 100ul
级    别: , , 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/10/12 8:57:00
详细资料:  实验方法技术资料
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诚信指数:1034点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-Diphtheria toxin fragment B/FITC Conjugated antibody

FITC标记的白喉毒素B抗体

 

英文名称 Anti-Diphtheria toxin fragment B/FITC
中文名称 FITC标记的白喉毒素B抗体
别    名 Diphtheria Toxin; DT; NAD(+)--diphthamide ADP-ribosyltransferase; Diphtheria toxin fragment B; DTX_CORBE.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Corynephage beta
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Diphtheria toxin fragment B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Diphtheria toxin is a 58 kDa protein secreted by lysogenic strains of Corynebacterium diphtheriae. The toxin causes the disease diphtheria in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis. The mechanism of inhibition involves transfer of the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive. The catalysed reaction is as follows: NAD + + peptide diphthamide = nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide The crystal structure of the diphtheria toxin homodimer has been determined to 2.5A resolution. The structure reveals a Y-shaped molecule of 3 domains, a catalytic domain (fragment A), whose fold is of the alpha + beta type; a transmembrane (TM) domain, which consists of 9 alpha-helices, 2 pairs of which may participate in pH-triggered membrane insertion and translocation; and a receptor-binding domain, which forms a flattened beta-barrel with a jelly-roll-like topology. The TM- and receptor binding-domains together constitute fragment B.

Function:
Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to eukaryotic elongation factor 2 (eEF-2). Fragment A is the catalytic portion responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.

Subcellular Location:
Homodimer.

Database links:

Entrez Gene: 2650491 CORBE

Swiss Prot: P00588 CORBE



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

白喉毒素是由白喉棒状杆菌裂解菌株分泌的58 kDa蛋白。毒素通过进入细胞胞浆和抑制蛋白质合成而导致人类白喉症。其抑制机制涉及NAD的ADP核糖基转移到伸长因子-2(EF-2),使EF-2失活。催化反应为:NAD++肽二***二甲酰胺=烟酰胺+肽N-(ADP-D-核糖基)二***二甲酰胺。该结构显示了一个Y形分子,包括3个结构域,一个催化结构域(片段A),其折叠为α+β型;一个跨膜(TM)结构域,它由9个α螺旋组成,其中2对可能参与pH触发的膜插入和易位;以及一个受体结合。IN域,它形成一个扁平的β桶,具有果冻卷状拓扑结构。Tm和受体结合域共同构成B片段。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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